原发性胆汁性肝硬化患者多种实验室指标分析及其诊断价值

Patients with Primary Biliary Cirrhosis Analyze a Variety of Laboratory Tests and Diagnostic Value

目的:分析75例原发性胆汁性肝硬化(PBC)患者实验室指标的特点,综合分析对PBC的诊断价值。方法:对75例确诊的PBC患者血清生化免疫球蛋白自身抗体等指标进行回顾性分析。结果:175例PBC患者血清碱性磷酸酶(ALP),γ-谷氨酸氨基转移酶(GGT),总胆红素(TBIL),总胆固醇(TC),免疫球蛋白M(Ig M)较对照组显著升高(P<0.05);谷丙转氨酶(ALT),谷草转氨酶(AST),总蛋白(TP),免疫球蛋白A(Ig A),免疫球蛋白G(Ig G)Ig G较对照组变化不明显(P>0.05);2自身抗体检测75例抗核抗体(ANA)均阳性,主要荧光核型为胞浆颗粒型,着丝点型,核点型,核仁型及混合型;75例患者抗线粒体抗体(AMA)阳性率为93.4%,AMA-M 2阳性率为85.3%。结论:综合多项实验室指标检测对PBC的诊断有着极其重要的价值。

Objective： To analyze 75 cases of patients with primary biliary cirrhosis （PBC） laboratory index, the character- istics of comprehensive analysis of the value to the diagnosis of PBC. Methods：75 patients with diagnosis of PBC serum bio- chemical indexes of immunoglobulin autoantibodies were retro- spectively analyzed. Results：①75 cases of PBC patients serum alkaline phosphatase （ALP） and gamma pancreatic acyl trans- ferase （GGT）, total bilirubin （TBIL）, total cholesterol （TC）, im- munoglobulin M （IgM） significantly increased than the control group （P 〈 0. 05）; Cereal third transaminase （ALT）, aspertate aminotransferase （AST）, total protein （TP）, immunoglobulin A （IgA）, immunoglobulin G （IgG） does not change significantly than control group （P 〉 0. 05）;②autoantibodies detection, 75 cases of antinuclear antibodies （ANA） are positive, main fluo- rescent karyotype for type cytoplasm particles, the centromere, nuclear point type, nucleolus type and mixed type; Antimito-cbondrial antibody （AMA）, 75 cases of patients with positive rate was 93. 4%, the AMA - M2 positive rate was 85.3%. Con- clusion：comprehensive many laboratory index detection has very important value to the diagnosis of PBC.