自身免疫性痴呆的临床特点及治疗措施

Autoimmune disease analysis of the clinical characteristics and treatment application

目的分析自身免疫性痴呆的临床特点及治疗措施应用的疗效。方法选取2010年2月至2014年12月本院收治的25例自身免疫性痴呆患者为研究对象,观察患者的临床表现、相关检查及治疗措施疗效。结果患者25例,男:女性别比例为(1.0:1.5)。其中,多发性硬化性痴呆9例,副肿瘤性边缘叶脑炎性痴呆6例,桥本脑病性痴呆3例,血管炎性痴呆3例,自身免疫性脑病性痴呆4例;均主要为急性、亚急性或波动性,慢性发病较少。性别、年龄等差异在疾病种类和分期方面比较差异无统计学意义(P>0.05)。治疗前所有患者均有记忆力下降,其中5例(20.0%)信息处理能力下降、7例(28.0%)注意力明显不集中、6例(24.0%)计算能力下降、9例(36.0%)执行能力下降、4例(16.0%)失语;治疗后各项相关检查指数分别为5例(20.0%)、1例(4.0%)、1例(4.0%)、2例(8.0%)、2例(8.0%)、1例(4.0%)、1例(4.0%),治疗前后比较差异有统计学意义(P>0.05)。结论自身免疫性痴呆患者针对其原发病进行免疫学治疗疗效较佳,能有效改善患者的记忆力、癫痫发作、执行力下降等症状。免疫学及影像学检查可以为疾病诊断提供有力支持。

Objective To analyze the effect of the clinical characteristics and treatment application of autoimmune disease curative effect.Methods in February 2010 to December 2014 in our hospital 25 cases of autoimmune dementia patients ,the clinical manifestations were observed and related checks.Results 25 patients, male： female ratio respectively （1.0： 1.5）.Among them, 9 cases of onset of the multiple sclerosis,mparaneoplastic limbic encephalitis have disease 6 cases、Hashimoto’ s encephalopathy have disease in 3 patients,vasculitis have disease in 3 patients, unclassified autoimmune disease onset in 4 cases; were mainly for acute, subacute, or volatility, less chronic onset.Gender, age differences in the types of diseases, such as staging areas and smaller differences, no significant （P〉0.05）.Before treatment all patients had symptoms of memory loss, including five cases （20.0%） decline in information processing capacity, seven cases （28.0%） was obviously not focus attention, 6 cases （24.0%） decrease computing capacity, 9 cases （36.0 %） decreased ability to perform, 4 cases （16.0%） aphasia; check the relevant index after treatment were five cases （20.0%）, 1 case （4.0%）, 1 case （4.0%）, 2 cases （8.0%）, 2 cases （8.0%）, 1 case （4.0%）, 1 case （4.0%）, there were compared before and after treatment was statistically significant （P〉0.05）.Conclusion Patients with autoimmune disease for the onset of the primary disease for immunological treatment curative effect is better, can effectively improve the patient＇s symptoms such as memory descent, epilepsy, execution, immunology and imaging examination can provide strong support for disease diagnosis.