口服米非司酮片联合局部注射甲氨蝶呤治疗剖宫产切口瘢痕妊娠的临床疗效观察

Analysis of mifepristone combined with methotrexate in the treatment of cesarean scar pregnancy

目的探讨剖宫产切口瘢痕妊娠的临床特点和治疗方法。方法 21例剖宫产术后子宫切口瘢痕妊娠患者采用子宫动脉栓塞治疗8例,米非司酮联合妊娠囊局部注射甲氨蝶呤治疗13例。结果两种治疗方案β绒毛膜促性腺激素(β-HCG)转阴时间分别为(28±0.3)d和(24±0.1)d;包块消失时间为(29±0.5)d和(25±0.7)d;平均住院日分别为(23±0.3)d和(18±0.2)d。结论剖宫产切口瘢痕妊娠早期明确诊断非常重要,口服米非司酮片联合彩超引导下妊娠囊局部注射甲氨蝶呤是一种安全有效的治疗方法。

Objective To investigate the clinical manifestation and pertinent treatment for cesarean scar pregnancy（CSP）.Methods 8 patients received uterine artery embolization and other 13 patients received mifepris-tone combined with methotrexate treatment .Results The time ofβ-HCG reducing to the nomal level were （28 ±0.3）d and （24 ±0.1）d in the above two groups respectively;Lumps disappear at （29 ±0.5）d and（25 ±0.7）d in the a-bove two groups respectively;The average hospital stays were （23 ±0.3）d and （18 ±0.2）d in the above two groups respectively .Conclusion Methotrexate combined with mifepristone is a safe and effective treatment for CSP .