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PI3K/AKT信号通路与辐射抵抗机制的研究概况

The PI3-K/AKT signaling pathway and radiation resistance mechanisms
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摘要 辐射抵抗的三个主要机制为内在辐射敏感性、肿瘤细胞增殖和乏氧。磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)信号通路是肿瘤细胞的存活通路之一,该通路的激活与辐射抵抗密切相关。该文就PI3K/AKT信号通路与辐射抵抗机制作一综述。 The three major radiation resistance mechanisms are intrinsic radiosensitivity, tumor cell prolifera-tion and hypoxia.The phosphatidy-linositol-3-kinase（PI3-K）/protein kinase B（AKT） pathway is one of the survival pathways of tumor cells .Activation of this pathway is closely related to radiation resistance .This review focuses on the PI3K/AKT signal pathway and radiation resistance mechanisms .
作者 秦俭 陆合明 陈甲信
机构地区 广西壮族自治区人民医院临床肿瘤中心放疗病区
出处 《中国临床新医学》 2015年第8期799-802,共4页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金 广西科学研究与技术开发计划项目(编号:桂科攻1140003B-69) 广西自然科学基金资助项目(编号:2010GXNSFB013081)
关键词 放射治疗 磷脂酰肌醇3激酶 蛋白激酶B 辐射抵抗 Radiotherapy Phosphatidy-linositol-3-kinase（PI3-K） Protein kinase B（AKT） Radia-tion resistance
分类号 R335.6 [医药卫生—人体生理学] R815 [医药卫生—放射医学]
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中国临床新医学
2015年 第8期

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