双相情感障碍患者检测血浆白蛋白、总胆红素、血清炎症因子和尿酸水平的临床意义

Diagnostic values of plasma albumin and total bilirubin,serum uric acid and inflammatory cytokines levels in patients with bipolar disorder

目的分析双相情感障碍患者检测血浆白蛋白和总胆红素、血清炎症因子和尿酸水平的临床意义。方法纳入48例双相情感障碍患者作为研究对象(观察组);选择同期健康体检者45例作为对照组;对比分析2组血浆白蛋白、总胆红素与血清IL-1β、IL-4、尿酸水平。结果观察组血浆白蛋白、总胆红素水平显著低于健康对照组,且具有统计学差异(P<0.05);观察组血清IL-1β、IL-4含量显著高于健康对照组,且具有统计学差异(P<0.05);观察组血清尿酸水平显著高于健康对照组,且具有统计学差异(P<0.05)。结论血浆白蛋白、总胆红素和血清IL-1β、IL-4、尿酸水平可作为诊断双相情感障碍参考指标。

Objective To analyze the diagnostic values of plasma albumin and total bilirubin, serum uric acid and inflammatory cytokines levels in patients with bipolar disorder.Methods A total of 48 cases of bipolar disorder patients were selected as research subjects （ study group） , and 45 cases of healthy people in the same period were chosen as control group.The plasma albumin, total bilirubin and serum IL-1β, IL-4, uric acid levels were compared and analyzed between two groups.Results The serum albumin, total bilirubin levels in study group were significantly lower than those in healthy control group, with significant difference （P〈0.05）.The serum IL-1β, IL-4 levels in study group were significantly higher than those in healthy control group, with a statistically significant difference （P〈0.05）.The serum uric acid levels in study group was significantly higher than that in healthy control group, with significant difference （P〈0.05）.Conclusion The serum albumin, total bilirubin and serum IL-1β, IL-4, uric acid levels can be used as a diagnostic reference index for bipolar disorder.