丹皮提取物对系统性红斑狼疮患者Th17细胞的影响

Effect of moutan cortex extract on Th17 cells of patients with systemic lupus erythematosus

目的：探究丹皮提取物对系统性红斑狼疮（ systemic lupus erythematosus，SLE）患者Th17细胞的影响。方法选择2012年3月～2013年8月在河南大学淮河医院接受治疗的SLE患者168例，以数字法随机法分为对照组和观察组，每组84例。对照组应用常规药物治疗，观察组在常规治疗基础上加用丹皮提取物治疗。对比2组治疗前后Th17细胞与Th1细胞百分率，并观察不良反应发生率。结果治疗前2组患者一般资料比较差异无统计学意义。治疗后观察组Th17细胞百分率下降至（0．27±0．15）％、Th1细胞上升至（2．53±1．72）％，均较对照组变化幅度更明显（ P＜0．05）。治疗后观察组IL－6水平、SLEDAI评分以及ESR均比对照组下降明显（ P＜0．05）。总不良反应发生率也显著少于对照组（ P＜0．05）。结论丹皮提取物能有效改善SLE患者病情，通过降低Th17细胞百分比及增加Th1细胞的百分比发挥作用，不良反应少。

Objective To study the effect of moutan cortex extract on Th17 cells of systemic lupus erythematosus （SLE） patients, so as to provide reference for clinical practice.Methods A total of 168 SLE patients admitted to our hospital from March 2012 to August 2013 were selected as subjects, andrandomized into the observation group and control group.84 patients in observation group received moutan cortex extract treatment and 84 patients in control group received conventional medical treatment.The Th17 and Th1 cell percentage of two groups before and after treatment were compared, and the incidence of adverse reactions were observed.Results All the indicators before treatment showed no statistically significant differences between two groups.After treatment, the Th17 cell percentage of observation group decreased to （0.27 ±0.15）%, and the Th1 cell percentage increased to （2.53 ± 1.72）%, showing more significant changes than control group （P〈0.05）.The reduction of IL-6 level, SLEDAI score and ESR after treatment were more significant in observation group than in control group（P〈0.05）.The incidence of adverse reactions was lower in observation group than in control group （ P 〈0.05 ） .Conclusion Moutan cortex extract can effectively improve the condition of SLE through reducing the Th17 cell percentage and increasing Th1 cell percentage with less adverse reactions.