喜炎平联合阿糖腺苷对小儿病毒性脑炎患者T细胞亚群的影响及其疗效观察

Effect of Xiyanping with vidarabine on T cell subgroup in children with viral encephalitis and its efficacy

目的：探究喜炎平与阿糖腺苷联合治疗小儿病毒性脑炎对T细胞亚群的影响及疗效观察。方法将2012年6月～2014年10月山东大学齐鲁儿童医院神经内科收治的106例病毒性脑炎患儿随机选分为观察组，对照组各53例。对照组在常规治疗的基础上给予喜炎平治疗，观察组在常规治疗的基础上，给予喜炎平联合阿糖腺苷治疗。持续治疗1周，观察比较2组T细胞亚群个数及各症状消失时间。结果治疗后2组T细胞亚群CD3＋、CD4＋、CD8＋个数显著增加，观察组增加个数显著高于对照组，差异均有统计学意义（P＜0．05）；观察组退热时间（2．5±1．1）d、头疼、呕吐消失时间（3．6±2．2）d、意识障碍消失时间（2．6±1．3） d及住院时间（9．3±2．4）d显著低于对照组（4．7±2．8）、（6．5±2．3）、（4．3±2．2）、（14．2±3．6）d，差异均有统计学意义（P＜0．05）；观察组疗效为优者占73．58％，优良率为92．45％，均显著高于对照组的52．83％，77．36％。差异均有统计学意义（ P＜0．05）；观察组并发症发生率16．98％、死亡率0．00％显著低于对照组33．96％、9．43％；观察组痊愈率（90．57％）显著高于对照组（49．06％）；观察组重度后遗症发生率11．32％显著低于对照组39．62％，差异均有统计学意义（P＜0．05）。结论喜炎平与阿糖腺苷联合治疗小儿病毒性脑炎可显著提高患儿T细胞亚群水平，改善临床治疗效果，安全性高。

Objective To explore curative effect of Xiyanping and vidarabine in treatment for children with viral encephalitis and its impact on T cells subgroup.Methods Methods In June 2012~October 2014, randomly selected 106 cases of children patients with viral encephalitis, as the research object.Randomized divided into observation group （n=53） cases, control group（n=53）.Both two group were performed routine therapy, and then control group was given Xiyanping treatment, observation group was given Xiyanping combined with vidarabine treatment.1 continuous week treatment, compared two groups of T cell subgroup number and symptoms disappear time.Results In the two groups after treatment of T cell subgroup CD3 ＋, CD4 ＋,CD8 ＋was significant increase in the number of observation group increased number was significantly higher than the control group,and statistically significant differences （ P〈0.05 ） .The observation group’s antifebrile time （ 2.5 ±1.1 ） d; headache, vomiting disappear time （ 3.6 ±2.2 ） d;disturbance of consciousness disappear time （2.6 ±1.3） d and length of hospital stay （9.3 ±2.4） d were significantly lower than the control group （4.7 ±2.8） d, （6.5 ±2.3）d, （4.3 ±2.2） d, （14.2 ±3.6） d, which were statistically significant differences （P〈0.05）.Observation group’s curative effect for instituting accounted for 73.58%, good rate 92.45%, were significantly higher than the control group 52.83%, 77.36%.which were statistically significant differences （P〈0.05）.The complication rate of observation group was 16.98%, mortality was 0%,were significantly lower than that of 33.96%, 9.43% of the control group;Cure rate of observation group （90.57%） was significantly higher than that of 49.06% of control group. Observation group severe sequela incidence 11.32% was significantly lower than that of 39.62% of control group and statistically significant differences （P〈0.05）.Conclusion Xiyangping combined with vidarabine in treatment for children with infantile viral encephalitis can significantly increase the number of T cell subgroup, improve immune function in children with, and curative effect is remarkable and high security.