阿托伐他汀钙对急性脑梗死患者血清ET-1、PAO、H-FABP、VEGF、S100β、炎症因子及神经功能的影响

Influence of lovastatin calcium on serum ET-1,PAO,H-FABP,VEGF,S100β,inflammatory cytokines and nerve function patients with acute cerebral infarction

目的探讨阿托伐他汀钙对急性脑梗死患者血清内皮素(endothelin-1,ET-1)、多胺氧化酶(polyamine oxidase,PAO)、心型脂肪酸结合蛋白(heart-type fatty acid binding protein,H-FABP)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、S100β、炎症因子及神经功能的影响。方法根据随机数字表法将本组纳入的113例患者随机分为观察组(n=61)和对照组(n=52)。对照组采用常规方法治疗,观察组在对照组基础上结合阿托伐他汀钙治疗。2组疗程均2周。对比分析2组治疗前、治疗7d和14d血清ET-1、PAO、H-FABP、VEGF、S100β、炎症因子水平及NIHSS评分。结果观察组血清ET-1、PAO、H-FABP水平治疗7 d、治疗14 d后显著低于对照组(P<0.05);观察组VEGF水平治疗7、14 d后显著高于对照组(P<0.05);观察组S100β水平治疗7、14 d后显著低于对照组(P<0.05);观察组hs-CRP、IL-8、TNF-α水平治疗7、14 d后显著低于对照组(P<0.05);观察组NIHSS评分治疗后显著低于对照组(P<0.05)。结论阿托伐他汀钙可通过降低血清ET-1、PAO、H-FABP、S100β水平,改善患者脑损伤及神经功能,通过促进VEGF高表达,促进血管新生,通过降低患者血清炎性因子水平,减轻炎症反应和缺血再灌注损伤,促进患者神经功能恢复。

Objective To investigate the effect of atorvastatin calcium on serum endothelin-1（ET-1）, polyamine oxidase（PAO）, heart-type fatty acid binding protein（H-FABP）, vascular endothelial growth factor（VEGF）, 100β, inflammatory cytokines and nerve function in patients with acute cerebral infarction.Methods According to the random number table, 113 patients were randomly divided into two groups （n=61） and control group （n=52）.The control group received conventional treatment methods, and observation group received atorvastatin calcium on the basis of control group. The treatment course was two weeks.Serum ET-1, PAO, H-FABP, VEGF, S100β, inflammatory cytokines and NIHSS score were compared between two groups before treatment, 7d and 14d after treatment.Results The serum levels of ET-1, PAO, H-FABP after 7d, 14d treatment of observation group was significantly lower than that of control group, respectively （P〈0.05）.The VEGF level of observation group after 7 d, 14 d treatment of observation group was significantly higher than that of control group, respectively （P〈0.05）.The S100βlevel after 7 d, 14 d treatment of observation group was significantly lower than that of control group, respectively （P〈0.05）.The hs-CRP, IL-8, TNF-αlevels after 7 d, 14 d treatment of observation group was significantly lower than that of control group, respectively （P〈0.05）.NIHSS score after treatment of observation group was significantly lower than that of control group （P〈0.05）.Conclusion The atorvastatin calcium can improve neurological function in patients with brain injury through reducing serum ET-1, PAO, H-FABP and S100βlevels, promote angiogenesis through increasing VEGF expression, and alleviate inflammation and ischemia-reperfusion injury through reducing inflammatory cytokines, thereby promote neurological functional recovery.