氢分子对心肌损伤的防护效应及机制

The Protective Effects and Mechanisms of Molecular Hydrogen in Cardiac Injury

近年来,氢分子的生物医学效应引起广泛关注.氢分子极小,且具有高扩散性,不仅能透过血脑屏障,还能穿过各种细胞膜进入胞浆、线粒体、细胞核和内质网等亚细胞结构,甚至可进入生物大分子内部,与靶分子发挥作用.近期研究表明,氢分子在缓解电离辐射、缺血再灌注、心脏移植、心肺复苏术和心肺转流术等所致心脏损伤中有很好的预防和辅助治疗效果,并且副作用极小.氢分子作用的机制可能与其抗氧化、抗炎、抗凋亡及调节线粒体代谢相关,但其确切机制还需更多和更深入的研究.

The biomedical effects of molecular hydrogen have aroused public and academic interest in recent years. Because of its high diffusivity and very small structure, hydrogen has the ability not only to cross the blood brain barrier, but also to infiltrate through the cytomembrane to the cytoplasm, mitochondria, nuclei, endoplasmic reticulum and other subcellular structures, even to interact inner motif of biomacromolecules. It has been proven that hydrogen shows effects on the prevention and treatment of cardiac injury induced by radiation, ischemia-reperfusion, cardiac allografts, cardiopulmonary resuscitation and cardiopulmonary bypass nearly without side effects. These effects have been suggested to be associated with its antioxidant activity, anti-inflammatory effect, anti-apoptosis and role in regulating of mitochondrial metabolism, but further studies are greatly needed for better and deeper understanding of the protective effects of hydrogen in cardiac injury.