摘要
IκB家族是一组能够与转录因子NF-κB直接结合并调节NF-κB活力的蛋白.IκB蛋白结构上的普遍特点是拥有负责与NF-κB结合的多个锚蛋白(ankyrin)重复序列.IκBL包含ankyrin的重复序列并且能够抑制LPS诱导的NF-κB激活.然而,IκBL与NF-κB能否直接结合仍不确定.本文综述了IκB家族成员结构和功能上的特点,并分析了IκBL是否应被视为IκB家族成员之一.
IκB family consists of a group of proteins that regulate the activity of transcription factor NF-κB by directly binding to NF-κB. The common structural feature of IκBS is the ankyrin repeats that are involved in NF-κB binding. IκBL contains ankyrin repeats and regulates LPS stimulated NF-κB activation. However, it is still unclear whether IκBL can bind to NF-κB directly. Here we reviewed structures and functions of IκB family proteins, and analyzed whether IκBL should be considered as a member of IκB family.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2015年第8期733-739,共7页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(81071743)
吉林大学唐敖庆教授启动资金
吉林省人才开发基金(802110000432)资助项目~~
