摘要
两亲性嵌段共聚物在水中可自组装形成的聚合物胶束。根据聚合物胶束的理化性质,它可通过被动靶向作用递送药物至肿瘤部位。在表面修饰配体或采用环境响应型材料制得的聚合物胶束可获得主动靶向性能,更利于抗肿瘤药在肿瘤部位大量聚集,提高疗效。此外,多功能聚合物胶束是近年来的研究方向之一。本文主要综述了具有主动靶向功能的聚合物胶束作为抗肿瘤药载体的研究进展。
Amphiphilic block copolymer can self-assemble in aqueous solution to form polymeric micelles. Polymeric micelles can deliver antineoplastic drugs to tumor site by passive targeting mechanism because of their physicochemical properties. Polymeric micelles with active targeting function can be obtained by surface modifying with targeting ligands or preparing with environmental stimuli-responsive materials. They are more favorable for delivering drugs to tumor site and improving therapeutic effect. In addition, multifunctional micelles are one of the research directions in recent years. This paper reviews the progress of polymeric micelles with active targeting function as antineoplastic drug carder.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第8期904-908,共5页
Chinese Journal of Pharmaceuticals
关键词
聚合物胶束
抗肿瘤药
主动靶向
综述
polymeric micelle
antineoplastic drug
active targeting
review
