大黄中药灌肠治疗慢性肾功能衰竭的作用机制研究

The mechanism of action of rhubarb Chinese medicine enema treatment of chronic renal failure

目的探讨大黄中药灌肠治疗慢性肾功能衰竭的临床疗效。方法以某院肾病科收治的92例慢性肾功能衰竭患者为研究对象,采用分组研究的方式,将其根据治疗方式不同分为对照组与观察组,对照组给予临床常规治疗,观察组在此基础上给予大黄为主的中药灌肠治疗,两组患者均治疗4周,在治疗结束后对比分析两组患者的治疗效果。结果观察组治疗总有效率为95.7%,明显高于对照组的75.1%(P<0.05);观察组临床症状改善情况优于对照组(P<0.05);两组患者尿素氮、肌酐水平均较治疗前有所改善,但观察组治疗后尿素氮、肌酐的改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论大黄中药灌肠治疗慢性肾功能衰竭的临床疗效显著,主要是通过改善血尿素氮及血肌酐情况来保护患者肾功能,可提高患者的生活质量,延长其生存期。

Objective Explore the rhubarb the clinical curative effect of traditional Chinese medicine enema treatment of chronic renal failure.Methods Kidney disease in a hospital treated 92 cases of chronic renal failure patients as the research object, with the method of grouping study, its according to different treatment can he divided into control group and observation group, control group for clinical routine treatment, observation group based on the given rhubarb is given priority to the traditional Chinese medicine enema treatment, two groups of patients were 4 weeks treatment, compared two groups of patients at the end of the treatment of therapeutic effect.Results Treatment the total effective rate was 95.7%, the observation group was obviously higher than that of control group 75.1% （P 〈 0.05） ; Group of clinical symptoms was observed is better than that of control group （P 〈 0.05） ; Urea nitrogen, creatinine, two groups of patients was improved, the but the observation group after treatment to improve the situation of urea nitrogen, creatinine, was better than control group, the difference was statistically significant （P 〈 0.05 ） .Conclusion Rhubarb Chinese medicine enema in the treatment of chronic renal failure clinical curative effect significantly, mainly by improving blood urea nitrogen and serum creatinine is to protect the patient＇s kidney function, can improve the patient＇s quality of life and prolong the survival period.