盐酸帕罗西汀治疗抑郁症的长期依从性及复发率的临床分析

Clinical analysis of long-term adherence and recurrence rate of paroxetine hydrochloride in the treatment of depression

目的探讨盐酸帕罗西汀治疗抑郁症的长期依从性及复发率。方法选取2011年1月~2013年6月收治的100例抑郁症患者作为研究对象,按照随机分配的方式,将其分为对照组（n=50）和观察组（n=50）。对照组患者使用阿米替林进行治疗,观察组患者使用帕罗西汀进行治疗。对两组患者进行为期2年的随访,观察患者的服药依从性、治疗效果、不良反应发生情况、复发情况。结果与对照组相比,观察组患者的服药依从性更高,复发率更低,不良反应发生率较低,差异均有统计学意义（P〈0.05）。结论使用盐酸帕罗西汀治疗抑郁症,其疗效显著,安全性较高,长期依从性较好,复发率较低。

Objective To study the long-term compliance and recurrence rate of paroxetine hydrochloride in the treatment of depression. Methods 100 patients with depression were research objects, and according to random distribution, divided into control group （n = 50） and observation group （n = 50）. The control group was treated with amitriptyline, and patients in the observation group were treated with paroxetine hydrochloride.The patient＇s medication compliance, treatment, adverse reactions, recurrence, were observed for 2 years of follow-up. Results Compared with the control group, the medication compliance of the observation group was higher （P 〈 0.05）, the recurrence rate is lower （P 〈 0.05） and adverse reactions occur rate is low （P 〈 0.05）. Conclusion The efficacy of paroxetine hydrochloride in the treatment of depression is obvious with higher safety, better long-term compliance, and lower the recurrence rate.