埃普利诺菌素注射剂对牦牛线虫及其寄生阶段幼虫驱虫效力的研究

Study on repellent effect of Eppley's rhzomorph injection on nematodes and larvae insect in parasitic stage in yak

选择6-8月龄自然感染消化道线虫和肺线虫的牦牛100头，按寄生虫感染情况搭配分为5组，每组20头，1-3组牦牛分别按0．1，0．2和0．3mg／kg．bW剂量皮下一次注射埃普利诺菌素注射剂，4组为药物对照组，按0．2m西瓜g剂量皮下注射伊维菌素注射剂，5组为阳性对照组，不给药。结果表明：埃普利诺菌注射剂O．2mg／kg剂量对消化道线虫（除毛首线虫外）的虫卵转阴率、减少率分别达90．O％和95．O％；对网尾线虫幼虫转阴率、减少率均达100．O％；对原圆科线虫幼虫转阴率、减少率分别达90．0％和92．5％；对线虫成虫、寄生阶段幼虫的总计驱虫率分别达97．8％和94．9％；0．3ms／kg剂量对消化道线虫（除毛首线虫外）的虫卵转阴率、减少率均达100．0％，；对网尾线虫幼虫转阴率、减少率均达100．O％；对原圆科线虫幼虫转阴率、减少率分别达95．0％和97．5％；对线虫成虫、寄生阶段幼虫的总计驱虫率分别达99．3％和97．7％；O．1mg／kg剂量对线虫虫卵（幼虫）的转阴率、减少率、驱虫率均低于0．2，0．3mg／kg剂量组；对照药物伊维菌素注射剂、0．2mg／kg剂量组对线虫的驱虫效果略低于同剂量埃普利诺菌素注射剂组；埃普利诺菌注射剂3个剂量组试验牦牛未见异常反应。试验证明埃普利诺菌注射剂0．1，0．2，O．3Ⅱ砂g体重剂量驱除牦牛线虫安全有效。其中以0．2mg／kg体重剂量经济高效。

100 yaks with aged from 6 te8 month, nematodes naturally infected gastrointestinal and lungworm were selected, divided into 5 groups according to the parasite infections, each group include 20 yaks, 1 - 3 groups of yak at 0.1, 0.2, and 0.3 mg/kg） b w dose,a subcutaneous injection of eppley rhzomorph respectively, 4 groups for drug control at 0.2 mg/kg dose of subcutaneous injection of iver- mectin ,5 groups is as the positive control group without administration. The results showed that the rate of turning negative, loss of nema- todes in gastrointestinal at 0.2 mg/kg dose of ppley＇s bacteria injection reach 90.0% and 95% respectively, reach 100.0% for nematode lar- vac . reach 90.0% and 92.5% respectively for original nematode larvae. The total insecticide rate of larvae was 97.8% and 94.9% respec- tively in parasitic stage for adult larvae. The rate of turning negative, loss of nematodes in gastrointestinal at 0.3 rag/leg dose reach 100.0%, reach 100.0% for tail nematode larvae , reach 95.0% and 97..5% respectively for original nematode larvae. The total insecticide rate of lar- vae was 99.3% and 97.7% respectively in parasitic stage for adult larvae. （The rate of turning negative, loss of nematodes,repellent rate at 0.1 mg/kg dose is low comparied with 0.2, 0.3 mg/kg dose group. The repellent effect of controlled drug of ivermectin injection, at 0.2 rag/ kg dose is slightly lower than applying samedose of eppley thzomorph injection It indicated that eppley injection at 0.1, 0.2, 0.3 mg/kg body weight dose is effective and safe for yaks. 0.2 mg/kg body weight dose is optimum.