西地那非联合护理干预治疗晚期特发性肺纤维化38例

The Effect of Sildenafil Combined with Nursing Intervention on Patients with Advanced Idiopathic Pulmonary Fibrosis in 38 Cases

目的观察西地那非联合护理干预治疗晚期特发性肺纤维化的疗效。方法将76例特发性肺纤维化患者随机分为对照组和观察组,各38例。对照组予甲基泼尼松龙治疗,观察组在对照组基础上联合西地那非治疗,两组患者均行针对性护理干预。分别观察两组患者治疗总有效率,治疗前后一氧化碳弥散量(DLCO)实测值/预计值(%)、动脉血氧分压(PaO2)、血氧饱和度(SaO2)、6 min步行试验(6MWT)等指标的改善情况。同时,观察两组患者治疗过程中不良反应。结果与对照组相比,观察组治疗总有效率显著提高,差异有统计学意义(P<0.05);治疗后两组患者DLCO%,PaO2,SaO2及6MWT较治疗前显著改善(P<0.05),且观察组前3个指标改善效果优于对照组(P<0.05),但6MWT改善水平未见明显差异(P>0.05);两组患者不良反应发生率比较未见明显差异(P>0.05)。结论西地那非联合护理干预能显著提高晚期特发性肺纤维化患者疗效,且治疗过程安全,值得临床推广。

Objective To detect the effect of sildenafil combined with nursing intervention on patients with advanced idiopathic pul-monary fibrosis. Methods 76 cases of idiopathic pulmonary fibrosis were randomly divided into control group and observation group, 38 cases in each group. The control group was given methyl - prednisolone treatment, the observation group in the control group based on the combined treatment with sildenafil. Two groups of patients for nursing intervention. The two groups were observed in patients before and after treatment, the total efficiency of treatment, diffusion capacity for carbon monoxide （DLCO） measured / predicted value% , arterial partial pressure of oxygen（PaO2 ）, oxygen saturation（SaO2 ）, 6 min walking test （6 MWT） to improve the situation index. At the same time to observe the adverse reactions of two groups of patients during treatment the incidence difference. Results Compared with the control group, the observation group total effective rate increased significantly, the difference was statistically significant（ P〈 0. 05） . Treatment of two groups of patients with DLCO% , PaO2, SaO2 and 6MWT significantly improved（ P〈 0. 05） after treatment, and obser-vation group to improve the level of treatment effect is better than the control group in the above indexes（ P〈 0. 05）, while the pa-tients in the two groups after treatment there was no significant difference between the 6MWT level of improvement（ P〉 0. 05） . Two groups of patients the incidence of adverse reaction was not significant difference（ P〉 0. 05） . Conclusion Sildenafil combined with nursing intervention can significantly improve the therapeutic effect on advanced idiopathic pulmonary fibrosis and the course of treat-ment with good security.