摘要
目的探讨舍曲林联合利培酮治疗老年强迫症(OCD)的疗效及安全性。方法将86例老年强迫症患者随机分为联合组和对照组,各43例。联合组给予舍曲林联合利培酮治疗,对照组仅给予舍曲林治疗。采用耶鲁-布朗OCD量表(Y-BOCS)评定疗效、不良反应症状量表(TESS)评定安全性。结果联合组治愈率为27.91%,显著高于对照组9.30%(χ2=4.914 3,P=0.026 6);联合组有效率为95.35%,显著高于对照组的58.14%(χ2=14.659 1,P=0.0001)。2组患者治疗2,4,8周末TESS评分均无统计学差异(P>0.05)。结论舍曲林联合利培酮治疗老年强迫症疗效显著,安全可行。
Objective To explore the therapeutic effects and safety of Risperidone combined with ziprasidone for elder patients with ob-sessive - compulsive disorder(OCD) . Methods The 86 elder patients with OCD were divided into combined group( n = 43) and control group( n = 43) randomly. The therapeutic effects and safety of the 2 groups were compared. The therapeutic effects was assessed by Yale - brown OCD scale (Y - BOCS) and the safety was assessed by Treatment, emergent symptoms (TESS). Results The curative rate of combined group (27. 91% ) was obviously higher than control group (9. 30% ,χ2 = 4. 914 3, P = 0. 026 6) and the effective rate of combined group (95. 35% ) was obvious higher than control group (58. 14% ,χ2 = 14. 659 1, P = 0. 000 1) . The TESS score of the 2 groups after treating for 2, 4, and 8 weeks was not obviously different( P〉 0. 05) . Conclusion Risperidone combined with ziprasidone is effective and safe for the treatment of elder patients with OCD.
出处
《中国药业》
CAS
2015年第15期100-101,共2页
China Pharmaceuticals
关键词
舍曲林
利培酮
强迫症
老年
疗效
不良反应
risperidone
ziprasidone
obsessive - compulsive disorder
elder
effect
adverse effect