阿司匹林联合氯吡格雷治疗进展性脑梗死33例

The Efficacy of Clopidogrel Combined with Aspirin for Progressing Stroke in 33 Cases

目的探讨阿司匹林联合氯吡格雷治疗进展性脑梗死的疗效。方法将66例患者随机分为治疗组和对照组,各33例。均给予常规治疗,对照组予阿司匹林150 mg/d口服,治疗组予氯吡格雷75 mg/d和阿司匹林100 mg/d口服。结果两组患者治疗前美国国立卫生院卒中量表评分(NIHSS)和Barthel指数(BI)评分无显著差异。治疗后14 d和28 d时,两组NIHSS评分均下降,治疗组低于对照组;两组BI分值均升高,治疗组高于对照组(P<0.05),治疗组总有效率显著高于对照组(P<0.05)。两组患者均未出现严重出血等不良反应。结论氯吡格雷联合阿司匹林治疗可改善进展性脑梗死患者神经功能缺损症状,且安全性良好。

Objective To evaluate the effect of clopidogrel combined with aspirin for progressing stroke. Methods 66 patients with pro-gressing stroke were divided to controlled group and treatment group, 33 cases of each group. The controlled group were randomized to receive aspirin 150 mg / d, treatment group were randomized to receive clopidogrel 75 mg / d plus aspirin 100 mg / d, both groups with routine treatments. Results After treatment for 14, 28 days. There is no significant difference in the NIHSS and the BI between the two groups before treatment. There was reduction in the NIHSS score and increase in the BI of both groups. The NIHSS score was lower and the BI was higher in treatment group than controlled group significantly（ P〈 0. 05） . Treatment group total effectiveness is signifi-cantly higher than the control group （ P〈 0. 05 ） . There was no severe adverse reaction such as major bleeding in both groups. Conclusion Clopidogrel combined with aspirin can improve neurological function in patients with progressing stroke.