维生素E干粉质量评价研究

Quality evaluation of vitamin E powder

目的：对喷雾干燥法生产的维生素E干粉进行质量研究，为维生素E干粉产品质量控制和应用提供科学依据。方法：对10个批次喷雾干燥法生产的维生素E干粉进行物理性质、化学性质和产品应用性评价，以外观、产品长期和加速稳定性、粒度分布、水分活度、休止角、松紧密度、冷水溶解性及漂油情况、水溶液及高糖高酸体系稳定性为指标，对喷雾干燥法生产的维生素E干粉的质量进行详细的考察。结果：喷雾干燥法生产的维生素E干粉为白色至类白色流动性粉末，无明显异物存在，加速稳定性试验条件下储存6个月和长期稳定性试验条件下储存36个月外观无明显改变；维生素E干粉的休止角为35．23±2．40°，水分活度为O．339±0．043，松密度为0．431±0．018g／cm3，紧密度为0．502±0．022g／cm3，粒度主要分布在60～100目之间；在加速稳定性试验条件下储存6个月的含量保留率为99．97±0．12％，长期稳定性试验条件下储存36个月的含量保留率为99．98±0．32％；维生素E干粉在冷水呈小蝌蚪状拖尾下落，并且在冷水中均匀分散，搅拌均匀后无结团、无漂油；维生素E干粉在水溶液和高糖高酸体系中稳定性良好。结论：维生素E干粉冷水分散，稳定性好、应用性能优异。

Objective ： To conduct the quality research of vitamin E powder by spray drying method in order to provide the scientific basis for its quality control and application. Methods ： Physical properties, chemical properties and application performances were evaluated for 10 batches of vitamin E powder produced by spray drying method. The products＇ appearance, long-term and accelerated stability, particle size distribution, water activity, angle of repose, bulk density, compact density, cold water solubility and floating oil, the stabilities of aqueous solution and high sugar and high acid system were used as indexes, the quality of vitamin E powder were evaluated in detail. Results ： The appearance of vitamin E powder produced by spray drying method was white or almost white powder, no obvious suspicious objects, and the appearances had no obvious change under accelerated stability test for 6 months storage and the long term stability test for 36 months. The angle of repose, water activity, bulk density, compact density, particle size distribution of vitamin E powder was 35.23 ± 2.40° , 0.339 ± 0.043, 0.431 ± 0.018 g/cm3, 0.502± 0.022g/cm3, 60 - 100 mesh, respectively. The content retention rate of vitamin E powder was 99.97 ±0.12% and 99.98± 0.32% for 6 months storage and 36 month storage, respectively. The falling of vitamin E powder in cold water was like small tadpole-like tailing, and uniformly dispersed in cold water, no cluster and floating oil were formed. The stabilities of vitamin E powder in aqueous solution and high sugar and high acid system were all excellent. Conclusion ： Vitamin E powder can be dispersed in cold water with good stability and excellent performance.