血清谷氨酰转肽酶与2型糖尿病慢性肾脏疾病关系的研究

The relationship between serum glutamyltransferase and diabetic chronic kidney disease in patients with type 2 diabetes mellitus

目的探讨T2DM患者血清谷氨酰转肽酶(GGT)与糖尿病慢性肾脏疾病(CKD)的关系。方法选取糖尿病慢性肾脏疾病者(CKD组)160例和单纯T2DM者(T2DM组)166例,比较两组参数的差异,并对有差异的指标进一步行Logistic回归分析。结果 CKD组BMI、糖尿病病程、24hUAlb、TG、HbA1c、GGT、8-羟基脱氧鸟苷(8-OHdG)、3-硝基酪氨酸(3-NT)均高于T2DM组,而谷胱甘肽(GSH)、超氧化物歧化酶(SOD)低于T2DM组(P<0.05)。Logistic回归分析显示,糖尿病病程、HbA1c、GGT是CKD的危险因素(OR=3.38、4.43、6.80,P=0.003、0.012、0.008)。结论 GGT与CKD的发生存在相关性,可能是CKD的危险因素。

Objective To investigate the relationship between serum glutamyltransferase （GGT ） and diabetic chronic kidney disease （CKD） in patients with T2DM. Methods A total of 326 hospitalized T2DM patients were recruited from January 2012 to December 2014 ,including 160 with CKD （CKD group） and 166 without CKD （T2DM group）. All indexes were compared between two groups. Logistic regression analysis was performed to determine the risk factors of CKD. Results Compared with T2DM group ,BMI ,duration of diabetes ,24 h urine protein quantity ,TG ,HbA1 c ,GGT ,8‐OHdG ,and 3‐NT were significantly higher in CKD group;and the levels of GSH and SOD were significantly lower. Logistic regression analysis showed duration of diabetes ,HbA1c and GGT were associated with the development of CKD（OR= 3.38 ,4.43 ,6.80 ,P= 0.003 ,0.012 ,0.008）. Conclusion The findings show that the increased level of serum GGT may be a risk factor of CKD in T2DM.