Kiss1基因调控哺乳动物繁殖性能的研究进展

Research Progress on Reproduction Regulation of Kiss1 Gene in Mammals

Kiss1基因是近年来繁殖生理学领域的研究热点。Kiss1基因编码的多肽类激素叫Kisspeptin。Kiss1基因主要表达于下丘脑弓状核和下丘脑前腹部室旁核区域。Kisspeptin可通过其受体GPR54的介导来发挥作用。Kiss1基因是促性腺激素释放激素的关键上游调节子,在性腺轴系统中起到中枢节点作用。Kiss1在动物初情期启动、季节性发情、生殖调控中起着关键作用。论文就Kiss1基因在哺乳动物繁殖方面的研究进展进行简单综述。

Kissl gene has been extensively studied in reproduction physiology recently. Kisspeptins are a family of structurally related peptides encoded by the Kissl gene. Kissl is predominantly located in the arcuate nucleus and anteroventral periventricular nucleus of the hypothalamus. Kisspeptins act through binding and subsequent activation of the G protein-coupled receptor 54 （GPR54）, with ability to regulate gonadotropin-releasing hormone andhence hypothalamic-pituitary-gonadal axis. Kisspeptins have emerged as important gatekeepers in reproductive maturation and function, from sexual differentiation of the brain and puberty onset to adult regulation of gonadotropin secretion and the metabolic control of fertility. The recent research progress of Kissl in the mammal reproduction regulation was reviewed in the paper.