缺血修饰性白蛋白在ACS和AIS患者中的诊断价值

Diagnostic value of ischemia-modified albumin in acute coronary syndrome and acute ischemic stroke

目的：探讨外周血缺血修饰性白蛋白（ischemia－modified albumin，IMA）水平在急性冠脉综合征（acute coronary syn－drome，ACS）和急性缺血性脑卒中（ acute ischemic stroke，AIS）中的诊断价值。方法：收集2013年9月～2014年11月皖南医学院附属弋矶山医院急诊科收治的ACS和AIS患者及健康体检者全血标本，分为ACS组、AIS组和对照组，每组收集满50例为止。检测血清中IMA浓度。结果：IMA在ACS组和AIS组患者中的水平分别为（88．3±10．2） U／mL和（92．6±10．4） U／mL，显著高于对照组（71．6±9．8）U／mL（P＜0．001）。 ACS组和AIS组患者中IMA的水平与肌钙蛋白Ⅰ（Trop Ⅰ）水平间的关联无统计学差异（两组均为P＞0．05）。 IMA灵敏度在ACS组和AIS组中分别为86％和88％，特异性分别为92％和94％。结论：由诊断界值确定的灵敏度和特异度表明，IMA是ACS患者和AIS患者诊断的有益指标。

Objective：To assess the diagnostic value by measuring the level of serum ischemia modified albumin （ IMA） in early diagnosis of patients with acute myocardial ischemia（ACS） and acute ischemic stroke（AIS）.Methods：The whole blood samples were collected from the ACS and AIS patients（n=50） admitted to the Emergency Department of our hospital between September 2013 and November 2014,and health subjects（n=50）.Then the partici-pants were allocated to ACS group,AIS group and control group,and serum IMA levels were measure.Results：The serum IMA concentration was （88.3 ± 10.2）U/mL and （92.6 ±10.4）U/mL for ACS and AIS patients,which was higher than the healthy controls（71.6 ±9.8） U/mL,P〈0.001.IMA level and troponin I level were not significant between ACS patients and AIS patients（P〉0.05）,and IMA sensitivity and specificity were 86% and 92% in ACS group compared to 88% and 94% in AIS group.Conclusion：The serum IMA level may be a useful indicator in diagnosis of patients with acute myo-cardial ischemia and acute ischemic stroke.