巢湖地区^(131)I和ATD治疗Graves甲亢的疗效分析

Contrastive analysis on the therapeutic effects with ^(131)I and anti-thyroid drug against Graves' hyperthyroidism

目的:对比分析131I和抗甲状腺药物(anti-thyroid drug,ATD)在治疗Graves甲亢疗效方面的差异。方法:选取2013年5月~2014年8月在我科住院的Graves患者,共178人。以131I治疗者为观察组,有87人;以ATD治疗者为对照组,有91人;进行0.5~1.5年的跟踪随访,比较两组患者的治愈、好转、复发、早发甲减的情况。结果:观察组总有效率93.1%,总治愈率71.3%,早发甲减率19.5%,复发率3.4%;对照组总有效率81.3%,总治愈率37.4%,早发甲减率4.4%,复发率13.2%。观察组和对照组的早发甲减、总有效率、总治愈率、复发率均具有显著差异(P<0.05)。结论:在治疗Graves甲亢疗效上,131I相比较于ATD,其治愈率高,复发率低,副作用少,但是早发甲减发生率高。

Objective：To compare the therapeutic effects of with 131I and anti-thyroid drug（ATD） against Graves′hyperthyroidism.Methods：The clinical data were reviewed in 178 patients with Graves′hyperthyroidism undergone treatment in our department during May 2013 and August 2014,and the pa-tients were divided into observational group（n=87,treated with 131I） and control group（n=91,treated with ATD）,and followed from 6 months to one and half years.The two groups were compared regarding the curative rate,improvement,recurrence and incidence of early hypothyroidism.Results：The to-tal effective rate,total curative rate,incidence of early hypothyroidism and recurrence rate was 93.1%,71.3%,19.5% and 3.4% for the observational group,and 81.3%,37.4%,4.4% and 13.2% for the control group.The difference was significant（P〈0.05）.Conclusion：131I appears superior to ATD in therapy of Graves′hyperthyroidism,and leads to higher curative rate,lower recurrence rate and fewer complications,yet it may result in higher incidence of early hypothyroidism.