探讨胺碘酮治疗 AMI 合并室性心律失常对降低患者病死率及室颤发生率的临床意义

Clinical significance of amiodarone in treatment of AMI patients with ventricular arrhythmias for lower mortality rate and the incidence of ventricular fibrillation

目的：分析胺碘酮治疗急性心肌梗死合并室性心律失常中的应用价值。方法选择商丘市中心医院80例心肌梗死合并室性心律失常患者作为研究对象，采用掷硬币的方式将患者随机分为两组，对照组采用利多卡因治疗，观察组采用胺碘酮治疗，观察两组患者的病死率及室颤发生率，记录室性心律失常的发生次数、QRS 波时限、PR 间期值。结果观察组病死率及室颤发生率分别为0、2.5%，均低于对照组，差异有统计学意义（P ﹤0.05）。观察组室性心律失常的发生次数、QRS 波时限分别为（906.385±89.674）次、（0.070±0.005）s，均低于对照组，PR 间期为（0.151±0.002）s，高于对照组，差异有统计学意义（P ﹤0.05）。结论胺碘酮治疗 AMI 合并室性心律失常可有效抑制心律失常，有利于降低患者的病死率。

Objective To analyze the effect of amiodarone on acute myocardial infarction combined the ventricular arrhythmias. Methods Eighty patients with myocardial infarction complicating ventricular arrhythmia were chose as research objects,and patients were randomly divided into two groups,control group had lidocaine treatment,observation group had amiodarone treatment. The mortality and incidence of ventricular fibrillation was observed,and the occurrence of ventricular arrhythmia,duration of QRS wave,PR interval value was recorded. Results The mortality and incidence of ventricular fibrillation in observation group was respectively 0,2. 5% ,which was lower than that of the control group,the differences were significant（ P ﹤ 0. 05）. The ventricular arrhyth-mia occurrence frequency,duration of QRS wave in observation group was respectively（906. 385 ± 89. 674）,（0. 070 ± 0. 005）s,which were lower than those of the control group,PR interval duration was（0. 151 ± 0. 002）s,which was higher than that of the control group,the differences were significant（ P ﹤ 0. 05 ）. Conclusions Taking amiodarone treatment of AMI with ventricular arrhythmia,can effectively inhibit cardiac arrhythmia,and lower the mortality of patients.