组合式血液净化模式对MODS患者胰岛素抵抗的影响被引量：2

The effect of combination mode of blood purification on insulin resistance in MODS patients

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摘要目的研究组合式血液净化模式对MODS患者胰岛素抵抗的影响,探讨改善MODS患者胰岛素抵抗最佳血液净化模式。方法选取MODS患者60例,随机分为试验组(单一血液净化模式)和对照组(组合式血液净化模式),每组各30例。观察两组患者血糖(BG)、血糖标准差(BGSD)、血糖变异系数(BGCV)、普通胰岛素用量(Ins)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)、C反应蛋白(CRP)及试验组治疗前后指标变化情况。结果试验组BG、HbA1c、FINS、CRP、HOMA-IR、Ins均较对照组降低(P<0.05);试验组治疗前较治疗后BG、FINS、CRP、HOMA-IR、Ins均有下降(P<0.05),HbA1c无改善(P>0.05)。结论组合血液净化模式对MODS患者胰岛素抵抗的疗效明确,但其机制需进一步研究。 Objective To study the effect of combination mode of blood purification on insulin resistance in MODS patients and discuss the best mode of blood purification to improve insulin resistance in MODS patients.Methods A total of 60 MODS patients were selected and randomly divided into control group（single mode of blood purification）and treatment group（combination mode of blood purification）,each group of 30 cases.Blood glucose（BG）,glucose standard deviation（BGSD）,coefficient of variation of blood glucose（BGCV）,regular insulin dosage（Ins）,fasting insulin（FINS）,insulin resistance index（HOMA-IR）,HbA1 c,C-reactive protein（CRP）was observed before and after treatment.Results BG,HbA1 c,FINS,CRP,HOMA-IR,Ins of experimental group was lower than that of control group（P〈0.05）.After treatment,BG,FINS,CRP,HOMA-IR,Ins was declined in experimental group（P〈0.05）.After treatment,HbA1 cwas not changed in experimental group（P〉0.05）.Conclusion Combination mode blood purification may be more effective to insulin resistance in MODS patients.

作者杨德兴徐冕颜悦新钱传云刘荣

机构地区昆明医科大学第一附属医院急救医学部重症医学中心

出处《重庆医学》 CAS 北大核心 2015年第23期3204-3205,3209,共3页 Chongqing medicine

基金云南省科技厅-昆明医科大学联合项目(2014)

关键词血液滤过血浆置换胰岛素抗药性胆红素 hemofiltration plasma exchange insulin resistance bilirubin

分类号 R459.7 [医药卫生—急诊医学]

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