慢性复发性丙型肝炎的优化治疗疗效分析与比较

Analysis and comparison in optimized treatment of chronic recurrent hepatitis C

目的研究探讨慢性复发性丙型肝炎的优化治疗方案及其最新研究。方法选择2008年5月至2012年5月至该院传染病科就诊的慢性复发性丙肝的患者50例,分为两组,每组25例,甲组采用标准治疗延长疗程方案,乙组采用标准治疗加大剂量方案,通过观察两组的持续病毒学应答(SVR)来比较两组治疗方法的效果,并观察6个月后的复发情况。结果甲组获得32%的SVR率,乙组获得23%的SVR率;6个月后甲组的复发率为38%,乙组为43%,差异均有统计学意义(P<0.05)。结论甲组的标准治疗延长疗程方案的临床SVR率高于乙组。

Objective To optimize the treatment of chronic hepatitis C recurrence.Methods During May 2008 to May 2012,50 patients with chronic recurrent hepatitis C were chosen in the infectious department of our hospital.They were divided into two groups with 25 cases in each group.Group A was treated by standard extended treatment scheme,while Group B was treated by standard large dose scheme.The effect was estimated by the observation of sustained virologic response in the two groups（sustained virologic response,SVR）.Results 32% SVR rate was found in group A and 23% SVR rate was found in Group B.38%recurrence rate appeared in group A after six months and 43% recurrence rate occurred in group B,there were significant difference between two groups（P〈0.05）.Conclusion The standard extended treatment schemes of pegylated interferon and ribavirin is superior to group B in SVR rate.