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基于血清胱抑素C估算的肾小球滤过率在慢性心力衰竭患者中的检测意义 被引量：10

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摘要 目的探讨基于CysC估算的eGFR(eGFR-CysC)在慢性心力衰竭(CHF)患者中的变化及与心功能评价标志物N末端脑钠肽前体(NT-proBNP)的关系及意义。方法测定118例CHF患者(CHF组)和30例对照人群(对照组)的血清NTproBNP和CysC,利用公式:eGFR-CysC=78.64×CysC-0.964计算两组eGFR。分析NT-proBNP值对数转换后,CHF组和对照组间各指标差异、相关性。结果与对照组相比,CHF组血清NT-proBNP和CysC均增高(P<0.05),而eGFR-CysC降低(P<0.05)。NYHA各级NT-proBNP均高于对照组(P<0.05),NYHAⅢ、Ⅳ级CysC均高于对照组(P<0.05),Ⅲ、Ⅳ级eGFR-CysC均低于对照组(P<0.05)。随着CHF组NYHA等级的升高NT-proBNP、CysC逐渐升高,eGFR-CysC逐渐降低(P<0.05)。相关分析显示NT-proBNP与CysC呈正相关(r=0.528,P<0.01),与eGFR-CysC呈负相关(r=-0.513,P<0.01)。结论 CysC和eGFR-CysC是良好的评价慢性心力衰竭患者心肾功能的指标。
作者 唐洁 周孟君 刘运双 俸家富
机构地区 四川省绵阳市中心医院检验科 四川省绵阳市中心医院信息中心
出处 《重庆医学》 CAS 北大核心 2015年第23期3262-3264,共3页 Chongqing medicine
关键词 心力衰竭 神经肽类 利钠肽 脑 N末端脑钠肽前体 血清胱抑素C eGFR-CysC 心肾综合症
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献16

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二级参考文献8

共引文献12

同被引文献85

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引证文献10

二级引证文献85

重庆医学
2015年 第23期

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