78例儿童过敏性紫癜过敏原特异性IgE测定分析

Analysis of serum allergen- specific IgE in 78 children with Henoch Schonlein purpura

目的探讨儿童血清过敏原特异性IgE抗体与过敏性紫癜患儿的关系及其检测意义。方法采用免疫印迹法(Western blotting)检测2013年1月至12月间就诊于郑州大学第三附属医院的78例过敏性紫癜患儿血清过敏原特异性lgE抗体,并对结果进行回顾性分析。结果 78例过敏性紫癜患儿血清特异性lgE阳性患儿54例,阳性率69.23%,其中吸入组过敏原阳性率较高是霉菌组合24.35%、蟑螂21.79%;食物组过敏原阳性率较高是蟹17.95%、花生16.67%、海鱼组合15.38%。结论儿童过敏性紫癜的发生与吸入性过敏原和食物性过敏原都有密切关系,霉菌组合、蟑螂、蟹、海鱼组合是郑州地区过敏性紫癜患儿的主要过敏原。

Objective To investigate the relationshipand significance of serum allergen specific IgE antibody test in Henoch Schonlein purpura （HSP） children. Methods Serum specific IgE in 78 HSP children were detected by Western blotting from 2013 January to December in Third Affiliated Hospital of Zhengzhou University. Results Of all the 78 children, 54 cases were found positive. The total positive rate was 69. 23%, the most common inhalant allergens were mold combination （24.35%） and cockroach （21.79%）, the most common food allergens were crab （17.95%）, peanut （ 16. 67% ） and sea fish combination （ 15.38% ）. Conclusion Inhaled and food allergens were all closely associated with the occurrence of childhood HSP. Mold combination, cockroaches, crab, sea fish combination were the main allergens.