同型半胱氨酸与糖尿病肾病的相关性分析

Association between homocysteine levels and risk of nephropathy in type 2 diabetes mellitus

目的本研究旨在分析同型半胱氨酸(Hcy)与糖尿病肾病的相关性。方法收集108名2型糖尿病患者的一般资料及相关生化指标。将所有受试者分为非糖尿病肾病组、微量蛋白尿组、大量蛋白尿组及肾功能不全组。结果糖尿病病程、血肌酐、尿素氮、糖化血红蛋白及Hcy在各组间具有显著差异。线性回归分析结果显示,Hcy与血肌酐呈正相关(β=1.396,P=0.000)。结论本研究结果提示Hcy可能是糖尿病肾病发生的独立危险因素。

Objective To explore the relationship between plasma total homocysteine concentration and diabetic nephropathy in patients with type 2 diabetes. Methods One hundred and eight patients with type 2 diabetes were recruited in this cross - sectionalstudy. Plasma total homoeysteine concentration and other traditional risk factors for diabetic nephropathywere measured. Results All the patients were divided into four groups according to the level of serum creat- inineandalbuminuria： normoalbuminuric, microalbuminuria, macroalbuminuriaand renal function failure. Plasma total homocysteine levels were significant different among groups, as well as major traditional risk factors for diabeticnephropathy（ duration of diabetes and HbAlc）. Homocysteine was independent associated with serum creatinine levels. Conclusion Plasma total homocysteine concentration was independently associated with occurrence of diabetic nephropathy in Chinese patients. Future prospective studies are warranted to clarify the relationship.