459例中段尿培养阳性老年患者病原菌分布及药敏结果分析

Analysis on clinical distribution and drug resistance of pathogenic bacteria in 459 elderly patients with pathogens culture positive in mid- stream urine

目的分析老年患者中段尿培养病原菌的分布及耐药性,为临床合理用药提供参考。方法对解放军第四一一医院2012年1月至2013年12月459例老年患者中段尿培养阳性的病原菌资料进行回顾性分析。结果459株病原菌中革兰阴性菌238株,占51.95%,居前2位的是大肠埃希菌、肺炎克雷伯菌;革兰阳性菌127株,占27.67%,居前2位的是屎肠球菌和粪肠球菌;真菌94株,占20.48%。分离出大肠埃希菌106株,其中产超广谱β-内酰胺酶菌株76株,比例高达71.69%。结论老年患者中段尿培养的病原菌仍以大肠埃希菌为主,医院内定期分析和监测尿路感染病原菌分布及其耐药性,对合理使用抗菌药物具有重要指导意义。

Objective To analyze the distribution of pathogens and drug resistance of the mid - stream urine culture in elderly patients for the guidance of clinical rational use of antibiotics. Methods A retrospective analysis of the date of pathogen identification in mid - stream urine culture from 459 elderly patients in our Hospital from January 2012 to December 2013 was done. Results Totally 238 strains of 459 pathogens were Gram negative bacilli accounted for 51.95% ,the ma- jority was the Escherichia coli （E. coli） and klebsiella pneumoniae; Gram positive cocci accounted for 27.67% （127strains）. The majority was Enterococcus fasium and Enterococcus faecalis;Fungi accounted for 20. 48% （94 strains）. 71.69% （76/106） strains of E. coli produced extended spectrum beta lactamases. Conclusion E. coli is the main pathogen cultured from mid - stream urine. It might play an important role on rational antibacterial application to analyze the clinical distribution and drug resistance of pathogenic bacteria in urinary tract infection in hospital regularly.