高频环形电切与冷刀锥切治疗宫颈上皮内瘤变Ⅲ的疗效对比研究

Efficacy comparative study of high- frequency loop electrosurgical excision and cold knife cone biopsy in treatment of cervical intraepithelial neoplasia Ⅲ

目的对比宫颈环形电切术(LEEP)与冷刀锥切术(CKC)两种术式对宫颈上皮内瘤变(CIN)的治疗效果。方法随机选取2011年12月—2013年9月商丘市妇幼保健院收治的128例CINⅢ患者,随机分为观察组和对照组各64例,观察组应用宫颈环形电切术治疗,对照组应用冷刀锥切术治疗。对两组手术时间、手术出血量、切口愈合时间和治疗效果等方面进行比较。结果观察组在手术时间、手术出血量、切口愈合时间等方面明显优于对照组,差异有统计学意义(P<0.05)。观察组愈合率、病灶残余率、复发率及患者满意率分别为90.61%、4.69%、4.69%、92.19%,均优于对照组(P<0.05)。结论 LEEP较之CKC治疗宫颈上皮内瘤变更加安全有效,且手术时间短、出血量少,更适用于基层医院。

Objective To compare the effect of cervical loop electrosurgical excision procedure （LEEP） and cold knife eonization （CKC） two procedures for cervical intraepithelial neoplasia （C1N） treatment. Methods Selected in Decem- ber 2011 September 2013 our hospital 128 cases CINⅢ were randomly divided into observation group and control group each 64 cases, the observation group applied treatment of cervical loop eleetrosurgical excision procedure, the control group of cold knife eonization treatment. Two groups of operative time, blood loss, wound healing time and treatment effects were compared. Results Observation group in operative time, aspects of surgical bleeding, wound healing time was significantly better than the control group, the difference was statistically significant （ P 〈 0.05 ）. Observation group healing rate, residual lesion rate, recurrence rate and patient satisfaction rates were 90.61%, 4. 69%, 4.69%, 92. 19% , than the control group （ P 〈 0. 05 ）. Conclusion Compared with CKC LEEP treatment of cervical intraepithelial neoplasia is more safe and effective, and short operative time, less bleeding, more suitable for grass - roots hospitals.