摘要
目的观察滋源降压饮对气血亏虚型老年单纯收缩期高血压病的临床疗效。方法临床选择符合纳入标准的老年单纯收缩期高血压病患者60例,并将患者随机分为两组,每组各30例。治疗组给予滋源降压饮早晚各1次,同时晨起口服苯磺酸氨氯地平5 mg+氢氯噻嗪12.5 mg,每天1次,对照组给予安慰剂早晚各1次,同时晨起口服苯磺酸氨氯地平5 mg+氢氯噻嗪12.5 mg,每天1次,治疗前后分别观察患者的偶测血压、24小时动态血压、中医单项症状的变化情况并分别计算血压平滑指数。结果与对照组相比,治疗组在偶测血压疗效上,无显著差异(P=0.998);在24小时动态血压疗效上,无显著差异(P>0.05),而在血压平滑指数上,在收缩压和舒张压上,两者均有显著差异(P=0.007,P=0.000),且治疗组比对照组有更高的血压平滑指数;在症状改善方面,治疗组要明显优于对照组,两者的中医症候总疗效相比较,有显著差异(P=0.002)。结论滋源降压饮联合西药降压药物治疗老年单纯收缩期高血压病,不仅可以降低患者的血压水平,且与单纯服用西药降压相比,血压下降更为平稳,更可以改善患者的临床症状。
Objective To observe the clinical efficacy of Ziyuan Jiangya Decoction for treatment of qi and blood deficiency type of isolated systolic hypertension. Methods 60 cases of patients met the inclusion criteria were recruited and randomly divided into two groups, with 30 cases in each group. The treatment group was treated with Ziyuan Jiangya Decoction and amlodipine 5 mg + hydrochlorothiazide 12. 5 mg once daily, while the control group was treated with placebo, and amlodipine 5 mg + hydrochlorothiazide 12. 5 mg once daily. Before and after treatment, blood pressure, 24h ambulatory blood pressure, changes in individual symptoms of Chinese medicine were observed and blood pressure smoothness indexes were calculated. Results Compared with the control group, changes in random blood pressure and 24h ambulatory blood pressure were not significantly different in the treatment group (P 〉 0. 05). But blood pressure smoothness index was higher in the treatment group than in the control group, and both systolic and diastolic blood pressure were significantly different ( P = 0. 007, P = 0. 000). For the improvement in symptoms aspects, the treatment group was superior to the control group. Comparison of the efficacy clinical symptoms, there was significantly different ( P = 0. 002 ). Conclusion Ziyuan Jiangya Decoction combined with western antihypertensive medications in elderly patients with isolated systolic hypertension, can not only reduce blood pressure levels in patients, but also improve the patient' s clinical symptoms. Compared with simply taking blood pressure medicine, blood pressure is more stable when taking Ziyuan Jiangya Decoction combined with western antihypertensive medications.
出处
《环球中医药》
CAS
2015年第7期803-806,共4页
Global Traditional Chinese Medicine
关键词
老年
单纯收缩期高血压病
气血亏虚
临床疗效
双盲
安慰剂
Elderly
Isolated systolic hypertension
Qi and blood deficiency
Clinical efficacy
Double-blind
Placebo