高血压昼夜节律变化与慢性脑供血不足的相关性研究

The relation of circadian rhythm and chronic cerebral circulation insufficiency in hypertensive patients

目的分析慢性脑供血不足(CCCI)合并高血压患者及单纯高血压患者的动态血压特点,探讨高血压昼夜节律变化与CCCI的相关性。方法对62例CCCI合并高血压患者(CCCI组)及60例单纯高血压患者(对照组)行24h动态血压监测,并同时收集患者的临床数据。结果 CCCI组较对照组有更明显的血压昼夜节律异常,夜间平均收缩压(n SBP)、夜间平均舒张压(n DBP)、非杓型血压发生率均较对照组明显升高(P=0.02,P=0.03,P=0.00)。两组患者年龄、高血压病程、体质量指数、高脂血症、C反应蛋白、纤维蛋白原、空腹血糖、24h平均收缩压、24h平均舒张压(24h DBP)、日间平均收缩压、日间平均舒张压及血压晨峰发生率的比较,差异均无统计学意义(P>0.05)。结论血压昼夜节律异常可能与CCCI的发生、发展密切相关。

Objective To study the correlation of circadian rhythm and chronic cerebral circulation insuffi-ciency （CCCl）in hypertensive patients.Methods 62 patients diagnosed CCCl and hypertensive were assigned CCCl group,while 60 hypertensive patients served as control group.Their ambulatory blood pressure monitoring and the la-boratory data were collected.Results The nocturnal systolic blood pressure （nSBP）,nocturnal diastolic blood pres-sure （nDBP）,and non -dipping blood pressure were significantly higher in CCCl group than those in control group（P=0.02,P =0.03,P =0.00）.No relation was found between the other laboratory and clinic data.Conclusions The nSBP、nDBP and non-dipping blood pressure may play an important role in the development of CCCl in hypertensive patients.