亚临床甲状腺功能减退对老年冠心病患者代谢因素的影响

Effect of subclinical hypothyroidism on metabolism factors in elderly patients with coronary heart disease

目的研究亚临床甲状腺功能减退(亚临床甲减)对老年冠状动脉粥样硬化性心脏病(冠心病)患者代谢因素的影响。方法选取183例老年冠心病患者,其中合并亚临床甲减者78例,无合并亚临床甲减者105例,两组患者分别抽空腹血检测血清促甲状腺素(TSH)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、尿酸(UA)、空腹血糖(FPG)及C反应蛋白(CRP)的水平,进行两组间比较。结果与无亚临床甲减的冠心病患者比较,合并亚临床甲减的冠心病患者血TG、TC、CRP、UA、LDL水平均明显升高、HDL水平降低,差异有统计学意义(P<0.05或P<0.01)。两组患者空腹血糖(FPG)水平差异无统计学意义(P>0.05)。结论亚临床甲减加重老年冠心病患者的血脂、尿酸等代谢紊乱。

Objective To study the influence of subclinical hypothyroidism on metabolic factors of elderly patients with coronary atherosclerotic heart disease （CHD）.Methods We selected 183 cases of elderly with coro-nary artery disease,including 78 cases combined with subclinical hypothyroidism,and 105 patients without subclinical hypothyroidism.Two groups of patients were detected the serum thyroid stimulating hormone （TSH）,triglyceride （TG）,total cholesterol （TC）,high density lipoprotein （HDL）,low density lipoprotein （LDL）,uric acid （UA）,fast-ing blood glucose （FPG）and C reactive protein （CRP）level,and the detected parameters were compared between groups.Results Compared with without subclinical hypothyroidism groups,TG,TC,CRP,UA,LDL levels of the pa-tients in eldly with CHD were obviously higher.The differences were statistically significant （P〈0.05 or P〈0.01）. Conclusion Subclinical hypothyroidism aggravated metabolic disorders of lipid and uric acid in aged patients with coronary heart disease.