匹多莫德联合雷诺考特治疗儿童鼻后滴漏综合征临床分析

Efficacy of Combining Ray Naukauot and Pidotimod for Postnasal Drip Syndrome in Children

【目的】探讨匹多莫德联合雷诺考特治疗儿童鼻后滴漏综合征（PNDS）的疗效。【方法】102侧PNDS患儿随机分为对照组（C组）、雷诺考特组（R组）和雷诺考特联合匹多莫德组（R＋P组），每组34例。C组主要根据患儿的病因进行相关的治疗，R组在C组治疗的基础上给予雷诺考特喷鼻，R＋P组在R组治疗的基础上给予匹多莫德口服。治疗结束后比较三组患儿的治疗效果和治疗满意度；治疗结束后随访3个月，观察三组患儿的复发情况。【结果】三组患儿的治疗效果差异具有统计学意义（P〈0．05），三组患儿的复发率和治疗满意度差异无统计学意义（P〉0．05）。R组与C组之间的治疗效果、复发率和治疗满意度差异无统计学意义（P〉0．05）；R＋P组与R组之间的治疗效果、复发率和治疗满意度差异无统计学意艾（P〉0．05）；R＋P组的治疗效果、复发率和治疗满意度显著优于C组，差异具有统计学意义（P〈O．05）。【结论】匹多莫德联合雷诺考特治疗儿童PNDS能够提升治疗效果，降低复发率。

[Objective] To explore the efficacy of combining Ray Naukauot and pidotimod for postnasal drip syndrome （PNDS） in children. [Methods] A total of 102 patients with PNDS were randomly divided into control, Ray Naukauot （R） and pidotimod （P） groups （ n =34 each）. The control group received related treatments, the Ray Naukauot group had additional Ray Naukauot nasal spray and the pidotimod group took oral pidotimodthe. The efficacies and treatment satisfaction were compared among 3 groups after the end of treatment. Over a follow- up period of 3 months, the recurrence rates of 3 groups were observed. [Results] The differences among 3 groups had statistical significance in efficacy （ P 〈0.05）. Recurrent rate or treatment satisfaction showed no significant difference （ P 〉0.05）. Between Ray Naukauot and control groups in efficacy, recurrence rate and treatment satis- faction showed no significant difference （ P 〉0.05）. No significant difference existed in efficacy, recurrence rate or treatment satisfaction between pidotimod and Ray Naukauot groups （ P 〉0.05）. Efficacy, recurrence rate and treatment satisfaction were significantly better in pidotimod group than those in control group. And the differences were statistically significant （ P 〈0.05）. [Conclusion] A combination of pidotimod and Ray Naukauot may boost the efficacy and reduce recurrence rate in the treatment of postnasal drip syndrome in children.