度洛西汀治疗老年广泛性焦虑障碍对照研究

A control study of effect of duloxetine on elderly patients with generalized anxiety disorder

目的评价度洛西汀治疗老年广泛性焦虑障碍(GAD)的有效性与安全性。方法将100例广泛性焦虑障碍老年患者随机分为51例服用度洛西汀治疗组(研究组)和49例服用坦度螺酮治疗组(对照组),治疗4周。治疗前及治疗后第1、2、3、4周末采用汉密尔顿焦虑量表(HAMA)进行疗效评估,用治疗中需处理的不良反应症状量表(TESS)评估安全性。结果治疗后第4周末研究组有效率为64.7%,对照组有效率为65.3%,两组比较差异无统计学意义(P>0.05)。两组治疗后第1、2、3、4周末HAMA评分与各自治疗前比较均下降(P<0.01)。研究组(17.6%)总不良反应发生率与对照组(20.6%)比较差异无统计学意义(P>0.05)。结论度洛西汀治疗老年广泛性焦虑障碍有效且安全。

Objective To evaluate the efficacy and safety of duloxetine in elderly patients with generalized anxiety disorder （GAD）. Methods 100 elderly patients with GAD aged 60 years and above were randomized into study group （51 cases） treated with duloxetine and control group （49 cases） treated with tandospirone for 4 weeks. All patients were assessed with Hamilton Anxiety Scale （HAMA） and Treatment Emergent Symptom Scale （TESS） at baseline and at the end of the 1st, 2nd, 3rd, 4th week of the treatment to evaluate the efficacy and safety respectively. Results There was no significant difference in response rate at the end of the 4th week between study group and control group （ 64.7% vs. 65.3% , P 〉 0.05 ）. Scores of HAMA in both group decreased significantly at the end of the 1st, 2nd, 3rd, 4th week when compared with the baseline （P 〈 0.01 ）. There was no significant difference in frequency of side effects between study group and control group （ 17.6% vs. 20.6% , P 〉 O. 05 ）. There was no significant difference in response rate at the end of the 4th week between study group and control group （64.7% vs. 65.3% , Scores of HAMA in both group decreased significantly at the end of the 1st , 2rd , 3rd, 4rd week when compared with the baseline （P 〈 0.01 ）. There was no significant difference in frequency of side effects between study group and control group （ 17.6% vs. 20.6% , P 〉 0.05 ）. Conclusion Duloxetine is effective and safe in the treatment of generalized anxiety disorder in elderly people.