大黄人参方联合改良DCF方案治疗晚期胃癌临床研究

Clinical study of Dahuang- renshen decoction combined with modified DCF regimen chemotherapy on advanced gastric cancer

目的观察大黄人参方联合改良DCF方案治疗晚期胃癌的临床疗效及安全性。方法将64例晚期胃癌患者随机分为2组,治疗组32例予大黄人参方联合改良DCF化疗方案治疗,对照组32例予改良DCF方案化疗,21 d为1个化疗周期,所有患者致少接受2个周期化疗。观察2组客观疗效、生活质量、无进展生存期（PES）及不良反应。结果治疗组临床获益率90.63%,优于对照组（66.67%,P〈0.05）;治疗组治疗后卡氏评分（KPS）好转率、食欲增加率及体质量增加率均高于对照组,差异均有统计学意义（P〈0.05）;治疗组PFS较对照组明显延长（P〈0.05）。治疗组Ⅰ~Ⅱ级主要毒副反应中白细胞计数减少、血小板计数减少、贫血、恶心、呕吐、周围神经毒性及肝功能损害发生率低于对照组（P〈0.05）。结论大黄人参方联合改良DCF方案治疗晚期胃癌能提高临床获益率,提高生活质量,减轻化疗毒副反应,使患者更好耐受化疗。

Objective To observe the validity and security of Dahuang - renshen decoction combined with modified DCF regimen chemotherapy on advanced gastric cancer. Methods 64 patients with advanced gastric cancer were randomly divided into two groups. 32 patients in treatment group were treated by Dahuang - renshen decoction combined with modified DCF regimen chemotherapy. 32 patients in control group were treated by simple modified DCF regimen chemotherapy. A cycle of chemotherapy was 21 days. All patients received treatment for two cycles at least. The objective effect,life quality,progression free survival （PFS） and adverse reaction were observed in two groups. Results The clinical benefit rate in treatment group （90.63%） was superior to that in control group （66.67% ,P 〈 0. 05 ）. The karnofsky performance status （KPS） scale improve rate, appetite increase rate and body quality increase rate after treatment in treatment group were superior to those in control group, and the difference was statistically significant （ P 〈 0. 05 ）. The PFS in treatment group was longer than that in control group P 〈 0.05 ）. The occurrence rate of the grade 1 -2 major toxicity included leukopenia, therombocytopenia, anemia, nausea, vomit, neurotoxicity and hepatic damage in treatment group were lower than those in control group （ P 〈 0. 05 ）. Conclusion Combined therapy of Dahuang - renshen decoction and modified DCF regimen chemotherapy can enhance clinical benefit rate, improve life quality, reduce chemotherapy side effect, and improve patients＇chemotherapy tolerance.