COPD患者病情变化与瘦素及IL-6水平的相关性研究进展

Study on the Correlation between the Disease Condition Changes and Leptin,IL-6 Level in COPD Patients

慢性阻塞性肺疾病(COPD)是一种常见的不可逆性的慢性肺部疾病,患病率高,但可预防和治疗。COPD包括慢性支气管炎和肺气肿两类。COPD患者的重要特征之一是体质量减轻,这与血清瘦素和白细胞介素6(IL-6)水平相关,且瘦素可能是COPD急性加重期的炎性标志物并可评估疾病的严重程度。该文就COPD的临床症状、流行病学、发病机制、急性加重期及稳定期COPD患者的病情变化与血清瘦素及IL-6水平的相关性研究予以综述。

Chronic obstructive pulmonary disease（COPD）,is a kind of common irreversible chronic lung disease,prevalence,but prevention and treatment are available.COPD includes two categories：chronic bron-chitis and emphysema.One of the important features of COPD patients is weight loss,which is correlated with serum levels of leptin and IL-6.The leptin may be inflammatory markers of acute exacerbation of COPD and can be used to assess the severity of the disease.Here is to make a review of the correlation between the clini-cal symptoms of COPD, epidemiology, pathogenesis, acute exacerbation and stable stage of COPD patients with changes in serum leptin and IL-6 levels.