芩贝止咳颗粒质量标准研究

Study on Quality Standard of Qinbei Zhike Granules

目的：建立芩贝止咳颗粒的质量标准。方法：采用显微鉴别法和TLC法鉴别法进行定性鉴别,运用HPLC法测定处方中黄芩苷的含量。结果：显微鉴别特征明显,TLC法鉴别斑点清晰,分离效果良好,阴性对照无干扰;黄芩苷在0.057 6~0.345 6μg呈良好的线性关系,r=0.999 8。平均回收率为97.72%,RSD为0.85%。结论：所建立的方法专属性强、灵敏度高、重复性好,有利于该制剂的质量控制。

Objective： To establish the quality standards for Qinbei Zhike granules. Methods： The microscopic identification and thin layer chromatography （ TLC ） was adopted for qualitative identification ; baicalin was detected by HPLC. Results： Microscopic identification features, The TLC spots were clearly and separated well, and the negative control did not impose any disturbance, baiealin showed a good linear relationship in the range of 0.057 6-0.345 6 μ g, （ r=0.999 2 ） and the average recovery was 98.48% （ RSD 1.03% ）. Conclusion ： The method was specific, sensitive and repeatable, can be used to control the quality of lancong tea better.