双阴性T细胞在肿瘤免疫治疗中的研究进展

Advances in double negative T cells in tumor immunotherapy

双阴性T细胞（即DNT细胞）是一种细胞表型为TCR＋ CD3＋ CD4-CD8-的特殊的调节性T细胞,分为αβT和γδT两群,在调节免疫反应中起着十分重要的作用.既往人们对DNT细胞研究主要局限于自身免疫性疾病和器官移植免疫方面.近年来,DNT细胞的过继免疫治疗作为一种新型的抗肿瘤方法逐渐走进公众的视野.本综述主要对DNT细胞来源分群、抗肿瘤作用及其可能的作用机制进行描述.

Double negative T cells,namely DNT cells,are specific regulatory cells with TCR＋ CD3 ＋ CD4-CD8-in cell phenotype,divide into αβ T cell and γδ T cell,play a very important role in regulating immunoreaction.Previous research restricted to the treatment of autoimmune disease and organ transplantation immunity.Recently dnt cells adoptive immunotherapy,as a new anti-tumor method,gradually come into public view.This review mainly focuses on the source of DNT cells,their anti-tumor effect,as well as the possible mechanism.