妊娠期高血压患者血浆中NO、ET-1及MCP-1水平变化及临床意义分析

Changes and clinical significances of plasma NO,ET-1 and MCP-1 levels in patients with hypertensive disorder complicating pregnancy

目的探讨妊娠期高血压(HDCP)患者血浆中一氧化氮(NO)、内皮素-1(ET-1)及单核细胞趋化蛋白-1(MCP-1)水平变化及临床意义。方法选取妊娠期高血压疾病患者90例按病情轻重分为重度子痫前期组、轻度子痫前期组及妊娠期高血压组,另选同期健康妊娠者30例作为对照组,比较血浆中NO、ET-1及MCP-1水平。结果重度子痫前期组、轻度子痫前期组及妊娠期高血压组收缩压(SBP)及舒张压(DBP)较对照组明显升高,差异有统计学意义(P<0.05);重度子痫前期组、轻度子痫前期组及妊娠期高血压组较对照组NO水平明显降低,ET及MCP-1水平明显升高,差异有统计学意义(P<0.05);重度子痫前期组、轻度子痫前期组及妊娠期高血压组组间NO、ET-1及MCP-1水平差异有统计学意义(P<0.05);妊娠期高血压患者血浆中NO、ET-1及MCP-1水平间呈明显相关性。结论血浆中NO、ET-1及MCP-1水平失衡在HDCP疾病发生中具有重要作用。

Objective To explore the changes and clinical significances of plasma nitric oxide（NO） ,endothelin‐1（ET‐1） and monocyte chemoattractant protein‐1（MCP‐1） levels in the patients with hypertensive disorder complica‐ting pregnancy（HDCP） .Methods 90 patients with HDCP were selected and divided into the severe preeclampsia group ,mild preeclampsia group and HDCP group according to the disease condition and contemporaneous 30 normal pregnancy women were chosen as the control group .The levels of plasma NO ,ET‐1 and MCP‐1 were tested and con‐duct the comparative analysis .Results The systolic blood pressure（SBP） and diastolic blood pressure（DBP） of the HDCP group ,mild preeclampsia group and severe preeclampsia group were significantly higher than those of the con‐trol group ,the differences were statistically significant（P〈 0 .05） ;the NO level of the HDCP group ,mild preeclamp‐sia group and severe preeclampsia group were significantly lower than that of the control group ,while the levels of ET‐1 and MCP‐1 were decreased ,the differences were statistically significant（P〈0 .05） ;the levels of NO ,ET‐1 and MCP‐1 had statistically significant difference among 3 groups（P〈 0 .05） ;the levels of plasma NO ,ET‐1 and MCP‐1 in the patients with HDCP showed the obvious correlation .Conclusion The imbalance of plasma NO ,ET‐1 and MCP‐1 plays an important role in the occurrence of HDCP .