N-末端脑钠肽前体在心力衰竭患者心功能分级中的应用

Application of NT-proBNP in cardiac function grading in patients with heart failure

目的：探讨 N‐末端脑钠肽前体（NT‐proBNP）在慢性心力衰竭（CHF）患者心功能分级中的应用。方法选取2013年1～12月延安大学附属医院心内科住院的Ⅱ～Ⅳ级慢性心力衰竭（CHF）患者105例作为 CHF组，另选取同期健康体检人员45例作为对照组。比较2组人群血清 NT‐proBNP 及 CHF 组左室射血分数（LVEF）。结果 CHF 组血清 NT‐proBNP 平均水平2343 pg／mL ，明显高于对照组37．21 pg／mL ，差异有统计学意义（P＜0．01）；CHF 组血清 NT‐proBNP 水平与 NYHA 分级呈正相关（r ＝0．697，P＜0．01），LVEF 与血清 NT‐proBNP 水平呈负相关（r＝－0．573，P＜0．01）。结论血清 NT‐proBNP 水平是心功能状态的敏感指标，与心衰严重程度正相关，因此可作为诊断及危险分层的重要指标。

Objective To investigate the application of nitrogen‐terminal pro‐brain natriuretic peptide （NT‐proBNP） in the cardiac function grading in patients with heart failure .Methods 105 cases of grade Ⅱ - Ⅳ chronic heart failure（CHF） in the Affiliated Hospital of Yan′an University from January to December 2013 were selected and at the same period 45 healthy people undergoing physical examination were selected as the control group .Serum NT‐proBNP levels and the left ventricular ejection fraction（LVEF） were compared between the two groups .Results The mean serum NT‐proBNP level in the CHF group was 2 343 pg/mL ,which was significantly higher than 37 .21 pg/mL in the control group ,the difference was statistically significant（P〈 0 .01） ;serum NT‐proBNP level was significantly positively correlated with the NYHA classification（r= 0 .697 ,P〈0 .01） ,LVEF was significantly negatively correla‐ted with serum NT‐proBNP level（r= - 0 .573 ,P〈0 .01） .Conclusion Serum NT‐proBNP level is a sensitive indica‐tor of cardiac function status ,is positively correlated with the severity of heart failure ,and therefore can be used as an important indicator in the diagnosis and risk stratification .