行为疗法联合托特罗定治疗女性膀胱过度活动症伴急迫性尿失禁的疗效观察

Observation on effect of behavioral therapy combined with tolterodine in treating female overactive bladder complicating urge urinary incontinence

目的探讨行为疗法联合托特罗定治疗女性膀胱过度活动症(OAB)伴急迫性尿失禁(UUI)的临床疗效。方法选取北京市清河社区卫生服务中心就诊的女性OAB伴UUI患者91例,按就诊时间随机分为2组,A组45例,给予口服托特罗定8周;B组46例,给予行为疗法联合口服托特罗定联合治疗8周。比较2组治疗后患者的排尿日记、生活质量评分和尿流动力学检查结果。结果治疗后2组患者24h排尿次数、24h尿失禁次数均明显减少,每次排尿量、膀胱测压容积均明显增加,生活质量评分均改善,B组较A组效果更明显,差异有统计学意义(P<0.05)。结论行为疗法联合托特罗定比单用托特罗定治疗女性OAB伴UUI更有效。

Objective To investigate the clinical effect of the behavioral therapy combined with tolterodine in treating female overactive bladder（OAB） complicating UUI .Methods 91 cases of female pateints with OAB compli‐cating UUI in our center were randomly divided into the two groups according to the visiting time sequence .The group A（45 cases） was treated by oral tolterodine and the group B（46 cases） was treated by the behavioral therapy combined with tolterodine for 8 weeks .The urination daily record ,scores of life quality and urodynamic detection re‐sults after treatment were compared between the two groups .Results The mean 24 h urination frequency and 24 h incontinence frequency after treatment in the two groups were significantly decreased ,each urination volume and bladder pressure volume were significantly increased ,and the life quality was improved ,but the effects in the group B were more significantly than those in the group A ,the differences were statistically significant（P〈 0 .05） .Conclusion The behavioral therapy combined with tolterodine is more effective in treating female OAB and UUI than singletolterodine .