液基薄层细胞学在宫颈癌筛查中的应用

Application of liquid-based cytologic in cervical cancer screening

目的：探讨液基薄层细胞学（LBP）在宫颈癌筛查中的应用价值。方法选取2010年1月至2014年9月于广东省第二人民医院行宫颈 LBP 检查的8017例受检者为研究对象，根据年龄进行分组，观察结果阳性且愿意接受阴道镜及病理组织活检者的细胞学结果与组织学诊断的符合率。结果共有阳性人数703例，占8．8％，年龄17～70岁，40～49岁年龄组阳性率最高，达13．9％，各组间阳性率差异有统计学意义（χ2＝25．741，P＝0．000）；共有566例患者随后接受了阴道镜检查和病理组织活检，占80．5％，细胞学与组织学结果总符合率为62．5％，高级别病变符合率100．0％。结论 LBP 检查在宫颈癌筛查中具有操作简便、准确率高等优点，适合作为大范围宫颈癌筛查的首选方法。

Objective To study the application value of liquid‐based cytologic preparation（LBP） in cervical cancer screening .Methods A total of 8 017 cases of LBP in the Guangdong Provincial Second People′s Hospital from January 2010 to September 2014 were selected was the research subjects and divided into 5 groups according to age . The coincidence rate of the cytological results and the histological diagnosis in the patients with the positive results and willingly receiving the colposcopic examination and pathological biopsy was observed .Results There were 703 cases of positive results ,accounting for 8 .8% ,among them ,the youngest was 17 years old ,while the oldest was 70 years old ,the 40 - 49 years age group had the highest positive rate ,which reached 13 .9% ,the differences in the posi‐tive rate had statistical difference among groups（χ2 = 25 .741 ,P= 0 .000） ;Totally 566 cases accepted the colposcopic examination and pathological biopsy ,accounting for 80 .5% .The coincidence rate of cytology and histology was 62 .5% .The coincidence rate of high grade lesions was 100 .0% .Conclusion LBP has the advantages of simple oper‐ating and high accuracy and is suitable for the first choice for wide‐range cervical cancer screening .