瑞舒伐他汀对慢性心力衰竭患者血清细胞因子及心功能的影响

Influences of rosuvastatin on serum cytokines and cardiac function of patients with chronic heart failure

目的探究瑞舒伐他汀对慢性心力衰竭患者血清细胞因子和心功能的影响。方法选择广州市中医医院2014年5月到2015年5月收治的70例慢性心力衰竭患者,随机分为观察组和对照组,各35例。对照组采取抗心力衰竭常规治疗,观察组在常规治疗的基础上给予瑞舒伐他汀治疗。比较两组血清细胞因子水平以及心功能指标变化情况。结果观察组治疗后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)以及超敏C反应蛋白(hs-CRP)水平均显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗后LVESV水平显著低于对照组(P<0.05),LVEF显著高于对照组(P<0.05)。结论采用瑞舒伐他汀治疗慢性心力衰竭患者可显著调节血清细胞因子水平,改善心功能,值得临床广泛推广。

Objective To investigate the influences of rosuvastatin on serum cytokines and cardiac function of patients with chronic heart failure. Methods 70 patients with chronic heart failure treated in Guangzhou Hospital of TCM from May of 2014 to May of 2015 were randomly divided into observation group and control group,35 cases in each. The control group was given conventional anti- heart failure treatment,observation group was given rosuvastatin treatment on the basis of conventional therapy.The serum cytokine levels and cardiac function indicators were compared between two groups. Results After treatment,the levels of tumor necrosis factor- α（ TNF- α）,interleukin- 6（ IL- 6） and high- sensitivity C- reactive protein（ hs- CRP） in observation group were significantly lower than the control group,the difference was statistically significant（ P〈0. 05）. The level of LVESV in observation group was significantly lower than the control group（ P〈0. 05）; LVEF was significantly higher than control group（ P〈0. 05）. Conclusion Rosuvastatin could regulate the levels of serum cytokines,improve the cardiac function.It deserves the clinical expansion.