肝硬化病理学亚分类的研究进展

Research progress in pathological sub-classification of cirrhosis

打破肝硬化作为慢性肝病的最终阶段的单一病理框架,重构肝硬化多个阶段、多种方式动态演变的病理学亚分类概念,具有重要的理论和实践意义。初步研究提示,肝脏组织学参数纤维隔厚度、结节大小和基于纤维隔厚度、结节大小的La?nnec亚分期系统、Kumar亚分类系统以及基于数字图像分析的胶原面积比对肝硬化门脉高压和临床分期有一定的预测作用。在同病因和大样本基础上,以疾病发展和回归为参照,探索和验证肝硬化病理学亚分类及其相关组织学参数的有效性,应当是今后肝硬化病理学亚分类研究的主流方向。

Breaking single pathological frame of cirrhosis as end stage of chronic liver disease, and reconstructing the pathological sub-classification of cirrhosis as dynamic evolution with multiple stages and multiple forms, which has theoretical and practical importance. Preliminary findings suggest that the fibrous septum thickness and nodule size of histological parameters of liver tissue, and Laennec sub-stage system and Kumar sub-classification system based on the fibrous septum thickness and nodule size, collagen proportionate area based on digital image analysis, have predictive power for portal hypertension and clinical staging of cirrhosis. In basis of same cause and large sample, and taking disease progression and regression as the references, to explore and validate the effectiveness of pathological sub-classification of cirrhosis and the related histological parameters of liver tissue, which should be the main stream of future.