硫酸镁、酚妥拉明和硝苯地平联合治疗妊娠高血压综合征的临床分析

Clinical effect of magnesium sulphate combined with phentolamine and nifedipine in the treatment of pregnancy induced hypertension

目的观察硫酸镁、酚妥拉明和硝苯地平联合治疗妊娠高血压综合征（PIH）的临床效果。方法选取2012年1月~2015年3月我院收治的PIH患者124例,随机分为治疗组（n=62）和对照组（n=62）,对照组给予常规硫酸镁治疗,治疗组给予硫酸镁、酚妥拉明和硝苯地平联合治疗。观察记录两组患者的血压变化、治疗有效率、不良反应及妊娠结局。结果与对照组比较,治疗组患者用药后血压明显降低,治疗效果优于对照组,差异有统计学意义（P〈0.05）;患者无不良反应;妊娠结局明显改善,差异有统计学意义（P〈0.05）。结论硫酸镁、酚妥拉明和硝苯地平联合治疗PIH可获得较好的疗效,不良反应较少,可有效降低血压,改善围生结局。

Objective To observe the effect of magnesium sulphate combined with phentolamine and nifedipine treating pregnancy induced hypertension. Methods 124 patients with gestational hypertension treated from January 2012 to March 2015 were selected and they were randomly divided into treatment group（n=62） and control group （n=62）,treat-ment group was given magnesium sulphate combined with phentolamine and nifedipine,while control group was given simple magnesium sulphate,two groups were treated for 4 weeks.Observation the blood pressure,adverse reaction and the pregnancy outcome before and after treatment was used to evaluate the therapeutic effect between two groups. Results Systolic and diastolic blood pressure was significantly decreased respectively,effective rate of clinical was significantly increased in treatment group and control group after treatment,with statistical difference （P〈0.05）.Compared with control group,the pregnancy outcome was significantly improved after treatment in treatment group,with statistical difference（P〈0.01）,with fewer adverse reaction. Conclusion Magnesium sulphate combined with phentolamine and nifedipine treating pregnancy induced hypertension syndrome has better effect and safety.It is worthy of clinical promotion and application.