艾司西酞普兰与西酞普兰治疗抑郁症的临床效果比较

Clinical effect comparison of escitalopram and citalopram in the treatment of depression

目的观察艾司西酞普兰与西酞普兰治疗抑郁症的临床疗效,以期为抑郁症的临床治疗提供借鉴经验。方法选择2012年10月~2014年9月本院精神科收治的90例抑郁症患者,将其按照随机数字表法分为观察组和对照组,每组45例。对照组采用口服氢溴酸西酞普兰片治疗,观察组采用口服草酸艾司西酞普兰片治疗,两组均治疗6周后观察临床疗效和不良反应,并比较两组治疗前后汉密尔顿焦虑量表（HAMA）和临床总体印象量表-病情严重程度量表（CGI-SI）评分。结果两组的痊愈率和治疗总有效率差异均无统计学意义（P〉0.05）;治疗后,两组HAMA、CGI-SI评分均较治疗前显著降低,差异有统计学意义（P〈0.05）,但两组治疗后的比较,差异无统计学意义（P〉0.05）;两组不良反应发生率及治疗后不良反应量表总分差异无统计学意义（P〉0.05）。结论艾司西酞普兰与西酞普兰治疗抑郁症的效果相当,均可改善患者的病情和焦虑症状,且不良反应轻微,可以用于抑郁症的治疗。

Objective To observe the clinical efficacy of escitalopram and citalopram in the treatment of depression in order to enrich the experience of clinical treatment on depression. Methods 90 patients with depression in our hospital department of psychiatric from October 2012 to September 2014 were selected and evenly divided into observation group and control group by random number table,45 cases in each group.In the control group,oral administration of citalopram hydrobromide was provided,while in the observation group,escitalopram oxalate for oral administration was applied.After 6-week treatment,the clinical efficacy and adverse reaction in two groups was observed,and scores of Hamilton anxiety scale （HAMA） and clinical general impression-severity of illness scale （CGI-SI） between two groups before and after treatment was observed and compared. Results There was no significant difference in cure rate or total effective rate （P〉0.05）.After therapy,scores of HAMA and CGI-SI was greatly decreased compared with those before treatment with statistical difference （P〈0.05）,but didn’t display significant difference after treatment in both groups （P〉0.05）.Adverse reactions in two groups showed no important difference as well as score of emergent symptom scale （P〉0.05）. Conclusion Effect of escitalopram on treating depression is tantamount to citalopram.It can improve patient’s disease condition and anxiety with mild adverse reactions,which can be used to treat depression.