摘要
目的探讨18氟脱氧葡萄糖(18F-FDG)PET/CT对甲状腺结节的诊断价值。方法回顾性分析接受18F-FDG PET/CT检查并有明确病理结果的甲状腺结节患者79例(94个结节)。对比甲状腺恶性与良性结节的最大标准化摄取值(SUVmax),并进行ROC曲线分析,计算18F-FDG PET/CT诊断甲状腺良恶性结节的灵敏度、特异度、准确率、阳性预测值及阴性预测值。结果共94个结节,恶性、良性结节分别为53个(53/94,56.38%)和41个(41/94,43.62%)。甲状腺恶性、良性结节的SUVmax分别为7.15±5.09和2.58±1.19,差异有统计学意义(Z=5.33,P<0.01)。SUVmax诊断恶性甲状腺结节的ROC曲线下面积为0.82(95%CI:0.74~0.91,P<0.01),SUVmax界值为4.50时,灵敏度与特异度之和最大,为1.56。18F-FDG PET/CT诊断的灵敏度、特异度、准确率、阳性预测值及阴性预测值分别为79.25%(42/53)、80.49%(33/41)、79.79%(75/94)、84.00%(42/50)、75.00%(33/44)。结论 18 F-FDG PET/CT可以判断甲状腺良、恶性结节,SUVmax界值应为4.50。
Objective To investigate the value of 18F-FDG PET/CT in diagnosis of thyroid nodules. Methods All 79 pa- tients with 94 thyroid nodules confirmed by histopathology underwent 18F-FDG PET/CT. Maximum standardized uptake value （SUVmax） of benign and malignant thyroid nodules were compared, and ROC curve of SUVmax in diagnosis of malig- nant thyroid nodules were analyzed. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 18F-FDG PET/CT in diagnosis of malignant and benign thyroid nodules were calculated. Results There were 53 malignant （53/94, 56.38%） and 41 benign （41/94, 43.62%） thyroid nodules in 94 nodules. The SUVmax of malignant and benign thyroid nodules were 7.15±5.09 and 2.58±1.19, respectively （Z=5.33,P〈0.01）. The ROC area under curve for SUVmax in diagnosis of malignant thyroid nodules was 0.82 （95%CI： 0. 74-0. 91, P〈0.01）. When the SUVmax was 4.50, the sum of the sensitivity and the specificity was max of 1.56. The sensitivity, specificity, accuracy, positive predic- tive value and negative predictive value of 18 F-FDG PET/CT in diagnosis of malignant thyroid nodules were 79.25 % （42/ 53）, 80.49% （33/41）, 79.79% （75/94）, 84.00% （42/50）, 75.00% （33/44）, respectively. Conclusion 18F-FDG PET/ CT can differentially diagnosis of malignant and benign thyroid nodules, the SUVmax boundary value should be 4.5.
出处
《中国医学影像技术》
CSCD
北大核心
2015年第8期1178-1181,共4页
Chinese Journal of Medical Imaging Technology
