芽孢杆菌脂肽类抗生素的研究进展

Advances of Lipopeptides in Bacillus

脂肽类抗生素是芽孢杆菌产生的一类天然农用抗生素,具有广谱、高效、安全无毒、不易产生耐药性等优点,在芽孢杆菌生物防治方面发挥着重要作用。综述了目前国内外对脂肽类抗生素研究所取得的重要进展,包括脂肽类抗生素的种类和特性、快速分离鉴定、纯品制备、基因改造和发酵工艺优化等,并对脂肽类抗生素的研究前景进行了展望。

The lipopeptide from Bacillus is a kind of natural agricultural antibiotic and plays an important role in the biological control,duing to the advantages of broad-spectrum,efficient, non-toxic and so on.We reviewed the significant progress on lipopeptide,including the characters,isolation and identification, preparation of the pure product,genetic modification and optimization of the fermentation process. In addition,the potential application of lipopeptide are finally presented.