脆性组氨酸三联体蛋白在子宫内膜异位症中的表达

Expressions of FHIT in patients with endometriosis

目的：观察脆性组氨酸三联体（FHIT）蛋白在子宫内膜异位症（EMT）中的表达及意义。方法：应用免疫组化sP法检测FHIT在28例EMT患者（EMT组）的在位内膜、异位内膜及28例单纯子宫肌瘤患者（对照组）子宫内膜中的表达情况。结果：FHIT主要表达在子宫内膜腺体上皮细胞的胞浆和胞膜中。FHIT在EMT患者的在位内膜和异位内膜的阳性率分别为68％（19／28）和54％（15／28），两者相比差异无统计学意义（P〉0．05）；但均低于对照组的96％（27／28），差异有统计学意义（P〈0．05）；EMT不同re-AFS分期的异位子宫内膜中，FHIT的表达情况不同，Ⅰ～Ⅱ期的阳性率较Ⅲ-Ⅳ期的阳性率明显升高，差异有统计学意义（P〈0．05）。结论：FHIT可能与EMT的发病有关，并对疾病的严重程度有一定的影响。

Objective To observe the expression of fragile histidine triad （FHIT） protein in the endometriosis and its significance. Methods 28 pairs of samples of endometrium and ectopic endometrium from endometriosis （EMT） patients （EMT group）, and 28 endometrial samples from patients only with myoma of uterus （control group）were tested for the expression of FHIT by immunohistochemical SP method. Results FHIT was mainly expressed in the cytoplasm and membraneof endometrial glandular epithelial cells. The positive rate of FHIT expression in endometriumand ectopic endometrium from intrauterine membrane endometriosis （EMT group） patientwas 68% and 54%, which had no significant difference （P 〉 0.05）. However, the positive rate of FHIT expression in control group was 96% （27/28）, which is higher than those in the EM group, and the differences were statistically significant. The expression of FHIT was different indifferent stages of r-AFS in ectopic endometrium samples. The expression in stage Ⅰ - Ⅱ is higher than in stage Ⅲ-Ⅳ, with statistical significance. Conclusions FHIT may have some correlation with the development of endometriosis, and may have some influence on the severity of this disease.